MABC40

Anti-LAMP-2 Antibody, clone ABL-93

clone ABL-93, from rat

• Synonim(y): lysosomal-associated membrane protein 2, CD107 antigen-like family member B, CD107b antigen
• Kod UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Właściwości

• pochodzenie biologiczne: rat
• Poziom jakości: 100
• forma przeciwciała: purified immunoglobulin
• rodzaj przeciwciała: primary antibodies
• klon: ABL-93, monoclonal
• reaktywność gatunkowa: mouse
• metody: immunofluorescence: suitable; immunoprecipitation (IP): suitable; western blot: suitable
• izotyp: IgG2aκ
• numer dostępu NCBI: NP_001017959
• numer dostępu UniProt: P17047
• Warunki transportu: wet ice
• docelowa modyfikacja potranslacyjna: unmodified
• informacje o genach: mouse ... Lamp2(16784)

Opis

Opis ogólny

Lysosome-associated membrane protein 2 (LAMP-2) is a highly glycosolated protein belonging to the lysosome-associated membrane protein family. This group pf proteins composes a significant portion of the lysosomal membrane and are considered crucial mediators for cellular adhesion by interacting with carbohydrate receptors. LAMP-2 is a profuse and critical component of the lysosomal membrane as it has been implicated in playing a role in lysosomal biogenesis. It also appears to be involved in later stages of phagocytosis and autophagy, where it may act to protect the lysosomal membrane from being digested, assist in signal transduction, moderate levels of acidity within the lysosomal environment, and participate in adhesion. Mutations in LAMP-2 expression have been associated with lysosomal storage diseases or LSDs, along with Danon disease, an X-linked disorder characterized by skeletal myopathy, mental retardation, and hypertrophic cardiomyopathy.

Specyficzność

This antibody recognizes LAMP-2.

Immunogen

Purified glycoproteins from NIH/3T3 cells, corresponding to mouse LAMP-2.

Zastosowanie

Anti-LAMP-2 Antibody, clone ABL-93 is an antibody against LAMP-2 for use in WB, IP & IF.

Immunoprecipitation Analysis: This antibody has been shown to immunoprecipitate LAMP-2 in HaNIH cells, (Chen, 1985).

Immunofluorescence Analysis: This antibody has been shown to detect LAMP-2 in mouse brain, (Ferguson, 2009).

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

Jakość

Evaluated by Western Blot in NIH/3T3 cell lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected LAMP-2 in 10 µg of NIH/3T3 cell lysate.

Opis wartości docelowych

~ 80 kDa observed MW. The calculated MW is 45 kDa LAMP-2 is heavily glycosoated and has been routinely observed at MW′s of 80-120 kDa based on publication data, (Chen, 1985; Ferguson, 2009).

Postać fizyczna

Format: Purified

Protein G

Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Przechowywanie i stabilność

Stable for 1 year at 2-8°C from date of receipt.

Komentarz do analizy

Control
NIH/3T3 cell lysate

Inne uwagi

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 12 - Non Combustible Liquids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable