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AP130P

Sigma-Aldrich

Goat Anti-Mouse IgG & IgM Antibody, HRP conjugate

0.8 mg/mL, Chemicon®

Synonim(y):

Goat Anti-Mouse IgG Antibody

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About This Item

Kod UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.46

pochodzenie biologiczne

goat

Poziom jakości

białko sprzężone

peroxidase conjugate

forma przeciwciała

F(ab′)2 fragment of affinity isolated antibody

rodzaj przeciwciała

secondary antibodies

klon

polyclonal

reaktywność gatunkowa

mouse

producent / nazwa handlowa

Chemicon®

stężenie

0.8 mg/mL

metody

ELISA: suitable
western blot: suitable

Warunki transportu

wet ice

docelowa modyfikacja potranslacyjna

unmodified

Opis ogólny

Immunoglobulin G (IgG) is the most abundant immunoglobulin in the human serum. IgM constitutes 5-10% of total serum immunoglobulins. These immunoglobulins comprise four polypeptide chains with two heavy (H) chains and two light (L) chains. These polypeptide chains are inter-linked by disulfide bonds. IgM is a highly conserved antibody in vertebrates. IgM exists as a pentamer. Both IgG and IgM are secreted by B cells.

Zastosowanie

Goat Anti-Mouse IgG & IgM Antibody, HRP conjugate has been used in western blotting(1:400) and immunofluorescence (1:500)

Działania biochem./fizjol.

IgG facilitates antibody-dependent cell-mediated cytotoxicity (ADCC). It also aids in the activation of the classical pathway of the complement system. IgG neutralizes virus particles and toxins. IgM, an antibody that is expressed early during an immune response, aids in engulfing apoptotic cells. It exhibits polyreactive and autoreactive functionality. IgM induces tissue homeostasis by mediating the clearance of tissue-based molecules. Lower levels of IgM in serum are associated with increased autoimmune response and a higher risk of developing infections.

Informacje prawne

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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Kod klasy składowania

13 - Non Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable


Certyfikaty analizy (CoA)

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Hongsheng Wang et al.
Frontiers in immunology, 7, 99-99 (2016-03-26)
Most natural IgM antibodies are encoded by germline Ig sequences and are produced in large quantities by both mice and humans in the absence of intentional immunization. Natural IgM are reactive with many conserved epitopes, including those shared by microorganisms
Chun-Shan Han et al.
Experimental and therapeutic medicine, 14(1), 181-186 (2017-07-05)
The present study investigated the effect of rutin on high glucose-induced actin, α2, smooth muscle, aorta (ACTA2) and p38 protein expression in diabetic nephropathy (DN). Human mesangial cells were divided into a control group, high glucose-induced mesangial cell group, high
Triamcinolone reduces neovascularization, capillary density and IGF-1 receptor phosphorylation in a model of oxygen-induced retinopathy.
Hartnett, ME; Martiniuk, DJ; Saito, Y; Geisen, P; Peterson, LJ; McColm, JR
Investigative Ophthalmology & Visual Science null
Nelson K Chepkwony et al.
iScience, 24(9), 103071-103071 (2021-09-28)
Differences in ionic strength, pH, temperature, shear forces, and other environmental factors impact adhesion, and organisms have evolved various strategies to optimize their adhesins for their specific environmental conditions. Many species of Alphaproteobacteria, including members of the order Caulobacterales, use
Mari H Savolainen et al.
Neurobiology of disease, 68, 1-15 (2014-04-22)
The misfolding and aggregation of α-synuclein (aSyn) eventually lead to an accumulation of toxic forms that disturb normal neuronal function and result in cell death. aSyn rich inclusions are seen in Parkinson's disease, dementia with Lewy bodies and other synucleinopathies.

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