AG733
Tamm-Horsfall Glycoprotein
Synonim(y):
THP, UMOD, Uromodulin
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About This Item
Kod UNSPSC:
12352200
eCl@ss:
32160405
NACRES:
NA.41
Polecane produkty
pochodzenie biologiczne
human
Poziom jakości
Próba
>95%
Formularz
solid
producent / nazwa handlowa
Chemicon®
metody
activity assay: suitable
numer dostępu NCBI
numer dostępu UniProt
Warunki transportu
wet ice
informacje o genach
human ... UMOD(7369)
Powiązane kategorie
Opis ogólny
Research area: Immuno and CKS
Tamm-Horsfall glycoprotein (THGP) also known as uromodulin is abundantly present in mammalian urine. It is highly expressed in the thick ascending limb of the Henle′s loop in the kidney. This protein consists of three epidermal growth factor (EGF) domains and a zona pellucida-like domain. THGP is a member of the glycosylphosphatidylinositol (GPI) protein family and is attached to the cell membrane by a C-terminal GPI- anchor. The THGP gene is located on the human chromosome at 16p12.3.
Tamm-Horsfall glycoprotein (THGP) also known as uromodulin is abundantly present in mammalian urine. It is highly expressed in the thick ascending limb of the Henle′s loop in the kidney. This protein consists of three epidermal growth factor (EGF) domains and a zona pellucida-like domain. THGP is a member of the glycosylphosphatidylinositol (GPI) protein family and is attached to the cell membrane by a C-terminal GPI- anchor. The THGP gene is located on the human chromosome at 16p12.3.
Zastosowanie
Tamm-Horsfall Glycoprotein has been used in luciferase activity assay of immortalized proximal tubular cells and human primary proximal tubular epithelial cells. It has also been used as a standard for calibration of uromodulin in urine samples.
Działania biochem./fizjol.
Tamm-Horsfall glycoprotein (THGP) may play a role in antibacterial host defense, inflammatory kidney disease, and the urogenital tract. It exhibits protective effects against kidney stone formation by reducing the calcium oxalate precipitation. Mutations in the THGP gene lead to familial juvenile hyperuricemic nephropathy (FJHN), glomerulocystic kidney disease (GCKD), and medullary cystic kidney disease type 2 (MCKD-2).Tamm-Horsfall Protein (THP) mediates the formation of mucous coat of the bladder, thereby regulating the permeability of the ascending loop of Henle. THP is known to adhere to Escherichia coli strains with type 131 and type S32 fimbriae, thereby blocking their interaction with the uroepithelium. Additionally, THP activates cells by directly signaling through Toll-like receptor 4 (TLR4). It has been demonstrated that THP stimulates the production of tumor necrosis factor-alpha (TNF-α) and tissue factor in monocytes through TLR4.
Postać fizyczna
Lyophillized from deionized water containing 0.02% sodium azide.
Przechowywanie i stabilność
Store +2-8°C for up to 3 months after date of receipt.
DO NOT FREEZE.
DO NOT FREEZE.
Informacje prawne
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 1
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Certyfikaty analizy (CoA)
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Julie A D Van et al.
Molecular & cellular proteomics : MCP, 19(3), 501-517 (2019-12-28)
Chronic hyperglycemia is known to disrupt the proteolytic milieu, initiating compensatory and maladaptive pathways in the diabetic kidney. Such changes in intrarenal proteolysis are captured by the urinary peptidome. To elucidate the early kidney response to chronic hyperglycemia, we conducted
Aparna Renigunta et al.
The Journal of biological chemistry, 286(3), 2224-2235 (2010-11-18)
Tamm-Horsfall glycoprotein (THGP) or Uromodulin is a membrane protein exclusively expressed along the thick ascending limb (TAL) and early distal convoluted tubule (DCT) of the nephron. Mutations in the THGP encoding gene result in Familial Juvenile Hyperuricemic Nephropathy (FJHN), Medullary
Noel Edwards et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 32(12), 1994-1999 (2017-06-13)
Heterozygous mutations in UMOD encoding the urinary protein uromodulin are the most common genetic cause of autosomal dominant tubulointerstitial kidney disease (ADTKD). We describe the exceptional case of a patient from a consanguineous family carrying a novel homozygous UMOD mutation
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