ABT121

Anti-T-cadherin (CDH13) Antibody

from rabbit, purified by affinity chromatography

• Synonim(y): Cadherin-13, Heart cadherin, H-cadherin, P105, Truncated cadherin, T-cad, T-cadherin
• Kod UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Właściwości

• pochodzenie biologiczne: rabbit
• Poziom jakości: 100
• forma przeciwciała: affinity isolated antibody
• rodzaj przeciwciała: primary antibodies
• klon: polyclonal
• oczyszczone przez: affinity chromatography
• reaktywność gatunkowa: horse, human, rat
• reaktywność gatunkowa (przewidywana na podstawie homologii): mouse (based on 100% sequence homology), bovine (based on 100% sequence homology), equine (based on 100% sequence homology)
• metody: immunohistochemistry: suitable (paraffin); western blot: suitable
• numer dostępu NCBI: NP_001248
• numer dostępu UniProt: P55290
• Warunki transportu: wet ice
• docelowa modyfikacja potranslacyjna: unmodified
• informacje o genach: human ... CDH13(1012)

Opis

Opis ogólny

T-cadherin (CDH13), also known as Cadherin 13, is a member of the cadherin superfamily. This protein is unique from its other family members in that it lacks the cytoplasmic domains and is anchored to the cells membrane through the GPI anchor. T-cadherin is widely expressed in the cardiovascular system. Mutations in T-cadherin have been associated with many types of cancer.

Specyficzność

This antibody recognizes T-cadherin at the Cadherin 1 domain. This antibody detects the ~130 kDa pro-protein and the proteolytically cleaved ~105 kDa mature isoforms. (Denzel, M., et al. (2010). J Clin Invest.120(12):4342–4352.)

Immunogen

Epitope: Cadherin 1 domain

KLH-conjugated linear peptide corresponding to human T-cadherin at the Cadherin 1 domain.

Zastosowanie

Anti-T-cadherin (CDH13) Antibody detects level of T-cadherin (CDH13) & has been published & validated for use in WB, IH(P).

Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected T-cadherin in human brain and human heart tissues.

Research Category
Cell Structure

Research Sub Category
Adhesion (CAMs)

Jakość

Evaluated by Western Blot in human heart tissue lysate.

Western Blot Analysis: 0.1 µg/mL of this antibody detected T-cadherin on 10 µg of human heart tissue lysate.

Opis wartości docelowych

~130 and ~105 kDa observed.
~130 kDa corresponds to the pro-protein and ~105 kDa corresponds to the proteolytically cleaved mature isoform. (Denzel, M., et al. (2010). J Clin Invest.120(12):4342–4352.)

Postać fizyczna

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Przechowywanie i stabilność

Stable for 1 year at 2-8°C from date of receipt.

Komentarz do analizy

Control
Human heart tissue lysate

Inne uwagi

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 12 - Non Combustible Liquids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable