ABS85
Anti-CPT2 Antibody
serum, from rabbit
Synonim(y):
Carnitine O-palmitoyltransferase 2, mitochondrial, Carnitine palmitoyltransferase II, CPT II
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About This Item
Kod UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Polecane produkty
pochodzenie biologiczne
rabbit
Poziom jakości
forma przeciwciała
serum
rodzaj przeciwciała
primary antibodies
klon
polyclonal
reaktywność gatunkowa
rat
reaktywność gatunkowa (przewidywana na podstawie homologii)
human (immunogen homology)
metody
western blot: suitable
izotyp
IgG
numer dostępu NCBI
numer dostępu UniProt
Warunki transportu
wet ice
docelowa modyfikacja potranslacyjna
unmodified
informacje o genach
human ... CPT2(1376)
Opis ogólny
Carnitine palmitoyltransferase II (CPT2, or CPT II) belongs to the carnitine/choline acetyltransferase family. It is a ubiquitous protein found in the inner membrane of the mitochondria and plays an essential role in fatty acid β-oxidation. CPT2 is part of the system involving CPT1 and carnitine/acylcarnitine translocase (CACT), that facilitate the transport of long chain fatty acids into the mitochondrial matrix. CPT2 plays the role of restoring these molecules to original esterified forms suitable for β-oxidation, after they arrive in the matrix. Defects in CPT2 has varying outcomes: in adults, it results in episodes of rhabdomyolysis (breakdown of muscle fibers which circulate in the bloodstream), after prolonged and vigorous exercise; and in infants, CPT2 deficiency induces hypoketotic hypoglycemia and eventual cardiac damage.
Immunogen
KLH-conjugated linear peptide corresponding to human CPT2.
Zastosowanie
Anti-CPT2 detects levels of CPT2 proteins & has been published & validated for use in WB.
Jakość
Evaluated by Western Blot in rat liver mitochondria tissue lysate.
Western Blot Analysis: A 1:1,000 dilution of this antibody detected CPT2 on 10 µg of rat liver mitochondria tissue lysate.
Western Blot Analysis: A 1:1,000 dilution of this antibody detected CPT2 on 10 µg of rat liver mitochondria tissue lysate.
Opis wartości docelowych
~68 kDa observed (cleaved form). Uniprot gives a calculated weight of 74 kDa; however, CPT2 has been observed at ~68 kDa (Faye, A, et al. (2007). The Journal of Biological Chemistry. 282(37):26908–26916.). Uncharacterized bands appear at ~55, 58, 72, and 100 kDa in some lysates.
Komentarz do analizy
Control
Rat liver mitochondria tissue lysate
Rat liver mitochondria tissue lysate
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Kod klasy składowania
10 - Combustible liquids
Klasa zagrożenia wodnego (WGK)
WGK 1
Certyfikaty analizy (CoA)
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Audrey Faye et al.
The Journal of biological chemistry, 282(37), 26908-26916 (2007-07-26)
Carnitine palmitoyltransferase (CPT) 1A catalyzes the rate-limiting step in the transport of long chain acyl-CoAs from cytoplasm to the mitochondrial matrix by converting them to acylcarnitines. Located within the outer mitochondrial membrane, CPT1A activity is inhibited by malonyl-CoA, its allosteric
Andrea S Pereyra et al.
The Journal of biological chemistry, 292(45), 18443-18456 (2017-09-17)
Cardiac hypertrophy is closely linked to impaired fatty acid oxidation, but the molecular basis of this link is unclear. Here, we investigated the loss of an obligate enzyme in mitochondrial long-chain fatty acid oxidation, carnitine palmitoyltransferase 2 (CPT2), on muscle
Andrea S Pereyra et al.
Cell reports, 33(6), 108374-108374 (2020-11-12)
To assess the effects of acylcarnitine accumulation on muscle insulin sensitivity, a model of muscle acylcarnitine accumulation was generated by deleting carnitine palmitoyltransferase 2 (CPT2) specifically from skeletal muscle (Cpt2Sk-/- mice). CPT2 is an irreplaceable enzyme for mitochondrial long-chain fatty
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