ABN1737

Anti-BHLHE40/DEC1 Antibody

serum, from rabbit

• Synonim(y): Class E basic helix-loop-helix protein 40, bHLHe40, Class B basic helix-loop-helix protein 2, bHLHb2, Differentially expressed in chondrocytes protein 1, DEC1, Enhancer-of-split and hairy-related protein 2, SHARP-2, Stimulated by retinoic acid gene 13 pr
• Kod UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Właściwości

• pochodzenie biologiczne: rabbit
• Poziom jakości: 100
• forma przeciwciała: serum
• rodzaj przeciwciała: primary antibodies
• klon: polyclonal
• reaktywność gatunkowa: human
• reaktywność gatunkowa (przewidywana na podstawie homologii): rhesus macaque (based on 100% sequence homology), rat (based on 100% sequence homology), horse (based on 100% sequence homology), canine (based on 100% sequence homology), bovine (based on 100% sequence homology), mouse (based on 100% sequence homology)
• metody: western blot: suitable
• numer dostępu NCBI: NP_003661
• numer dostępu UniProt: O14503
• Warunki transportu: dry ice
• docelowa modyfikacja potranslacyjna: unmodified
• informacje o genach: human ... BHLHE40(8553) , DEC1(50514) , STRA13(201254)

Opis

Opis ogólny

Class E basic helix-loop-helix protein 40 (UniProt O14503; also known as Basic helix-loop-helix domain containing class B2, Class B basic helix-loop-helix protein 2, Differentially expressed in chondrocytes 1, Differentially expressed in chondrocytes protein 1, Differentiated embryo chondrocyte expressed gene 1, Enhancer-of-split and hairy-related protein 2, SHARP-2, Stimulated by retinoic acid gene 13 protein) is encoded by the BHLHE40 (also known as BHLHB2, DEC1, HLHB2, SHARP2, STRA13) gene (Gene ID 8553) in human. DEC1 (differentially expressed in chondrocytes 1) and DEC2 are E-box-binding transcription factors that exhibit a circadian expression pattern. Both proteins act to repress the Clock/Bmal1-activated E-box promoters via direct E-box binding rather than Bmal1 interaction. In addition, DEC1 is shown to negatively regulate the expression of DEC2. Markedly increased DEC1 expression is observed in colon carcinomas, whereas the opposite trend is seen with DEC2. Likewise cellular DEC1 over-expression results in a proportional decrease in DEC2 level.

Immunogen

Epitope: N-terminal

KLH-conjugated linear peptide corresponding to human BHLHE40/DEC1.

Zastosowanie

Anti-BHLHE40/DEC1 Antibody is an antibody against BHLHE40/DEC1 for use in Western Blotting.

Research Category
Neuroscience

Research Sub Category
Developmental Neuroscience

Jakość

Evaluated by Western Blotting in K562 nuclear extract.

Western Blotting Analysis: A 1:500 dilution of this antibody detected BHLHE40/DEC1 in 10 µg of K562 nuclear extract.

Opis wartości docelowych

~48 kDa observed. Uncharacterized band(s) may appear in some lysates.

Postać fizyczna

Rabbit polyclonal serum with 0.05% sodium azide.

Unpurified

Przechowywanie i stabilność

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Inne uwagi

Concentration: Please refer to lot specific datasheet.

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 12 - Non Combustible Liquids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable