ABE794

Anti-PCBP4 Antibody

from rabbit, purified by affinity chromatography

• Synonim(y): Poly(rC)-binding protein 4, Alpha-CP4, PCBP4
• Kod UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Właściwości

• pochodzenie biologiczne: rabbit
• Poziom jakości: 100
• forma przeciwciała: affinity isolated antibody
• rodzaj przeciwciała: primary antibodies
• klon: polyclonal
• oczyszczone przez: affinity chromatography
• reaktywność gatunkowa: human
• metody: immunocytochemistry: suitable; immunofluorescence: suitable; western blot: suitable
• numer dostępu UniProt: P57723
• Warunki transportu: wet ice
• docelowa modyfikacja potranslacyjna: unmodified
• informacje o genach: human ... PCBP4(57060)

Opis

Opis ogólny

PCBP4 (also known as MCG10, Poly (rC) binding protein 4 and alpha-CP4) is a member of the KH-domain RNA-binding protein family. Proteins of this family also referred to as alpha-CPs, bind to RNA with specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. PCBP4 is induced by p53 and DNA damage via two p53-responsive promoter elements. Its overexpression in transfected cells results in the suppression of cell proliferation by inducing apoptosis and cell cycle arrest in G2-M. Decreased expression of one isoform of PCBP4 has been observed in many forms of lung cancer, leading to speculation that PCBP4 can act as a tumor suppressor.

Immunogen

Epitope: C-terminus

KLH-conjugated linear peptide corresponding to a 17 amino acid peptide near the C-terminus of human PCBP4.

Zastosowanie

Anti-PCBP4 Antibody is a highly specific rabbit polyclonal antibody, that targets Poly (rC) binding protein 4 & has been tested in western blotting, ICC & Immunofluorescence.

Immunocytochemistry Analysis: 1 μg/mL from a representative lot detected PCBP4 in HeLa cells.

Immunofluorescence Analysis: 20 μg/mL from a representative lot detected PCBP4 in HeLa cells.

Research Category
Epigenetics & Nuclear Function

Research Sub Category
RNA Metabolism & Binding Proteins

Jakość

Evaluated by Western Blotting in HeLa cell lysate.

Western Blotting Analysis: 2 μg/mL of this antibody detected PCBP4 in HeLa cell lysate.

Opis wartości docelowych

~51 kDa observed. Uncharacterized bands may be observed in some lysate(s).

Postać fizyczna

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Przechowywanie i stabilność

Stable for 1 year at 2-8°C from date of receipt.

Inne uwagi

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 12 - Non Combustible Liquids
• Klasa zagrożenia wodnego (WGK): WGK 2
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable