ABE335

Anti-FOXL2 Antibody

from rabbit, purified by affinity chromatography

• Synonim(y): Forkhead box protein L2
• Kod UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Właściwości

• pochodzenie biologiczne: rabbit
• Poziom jakości: 100
• forma przeciwciała: affinity isolated antibody
• klon: polyclonal
• oczyszczone przez: affinity chromatography
• reaktywność gatunkowa: human
• reaktywność gatunkowa (przewidywana na podstawie homologii): porcine (based on 100% sequence homology), rabbit (based on 100% sequence homology), mouse (based on 100% sequence homology), bovine (based on 100% sequence homology)
• metody: western blot: suitable
• numer dostępu NCBI: NP_075555
• numer dostępu UniProt: P58012
• Warunki transportu: wet ice
• docelowa modyfikacja potranslacyjna: unmodified

Opis

Opis ogólny

Forkhead box protein L2 (FOXL2) is a fork-head transcription factor that is expressed in developing gonad and in granulosa cells of the mature ovary. It plays a role in repressing the development of testis, and facilitating the differentiation and maintenance of the ovary. Mutations in the FOXL2 gene result in blepharophimosis ptosis epicanthus inversus (BPES) syndrome, which is characterized by craniofacial defects and premature ovarian failure. FOXL2 has also been implicated in the development of ovarian granulosa cell tumors.

Specyficzność

Other homologies: Chicken (77% sequence homology).

Immunogen

KLH-conjugated linear peptide corresponding to human FOXL2.

Zastosowanie

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Chromatin Biology

This Anti-FOXL2 Antibody is validated for use in Western Blotting for the detection of FOXL2.

Jakość

Evaluated by Western Blot in human pituitary tissue lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected FOXL2 in 10 µg of human pituitary tissue lysate.

Opis wartości docelowych

~50 kDa observed. An uncharacterized band may appear at ~25 kDa in some lysates. The calculated molecular weight is 39 kDa, however FOXL2 has been shown as a ~50 kDa band in western blots (Marongiu, M., et al. (2010). PLOS One. 5(3):1-9).

Postać fizyczna

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Przechowywanie i stabilność

Stable for 1 year at 2-8°C from date of receipt.

Komentarz do analizy

Control
Human pituitary

Inne uwagi

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 12 - Non Combustible Liquids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable