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Key Documents

AB5727

Sigma-Aldrich

Anti-Sox10 Antibody

Chemicon®, from rabbit

Synonim(y):

Anti-Sox10 antibody, Sox10 marker

Zaloguj sięWyświetlanie cen organizacyjnych i kontraktowych


About This Item

Kod UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

pochodzenie biologiczne

rabbit

Poziom jakości

forma przeciwciała

affinity purified immunoglobulin

klon

polyclonal

oczyszczone przez

affinity chromatography

reaktywność gatunkowa

mouse

producent / nazwa handlowa

Chemicon®

metody

western blot: suitable

numer dostępu NCBI

numer dostępu UniProt

Warunki transportu

wet ice

docelowa modyfikacja potranslacyjna

unmodified

Opis ogólny

Sox 10 is part of a family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Sox 10 is expressed in multipotent neural crest stem cells, and its expression is downregulated upon their differentiation. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease.

Specyficzność

Sox10. The immunogen sequence is 70% conserved with Sox8 and Sox9 and therefore the antibody may show cross reactivity to these proteins.

Immunogen

Synthetic peptide from Sox10.

Zastosowanie

Anti-Sox10 Antibody detects level of Sox10 & has been published & validated for use in WB.
Research Category
Neuroscience
Research Sub Category
Developmental Neuroscience

Neuronal & Glial Markers
Western blot: 0.1-0.5 μg/mL using ECL on fetal mouse brain tissue lysate. The antibody reacts with proteins of ~60 kDa. An additional band of ~120 kDa may also be seen depending on sample used.

Optimal working dilutions must be determined by the end user.

Opis wartości docelowych

Approx. 55 kDa

Powiązanie

Replaces: AB5774

Postać fizyczna

Affinity purified immunoglobulin. Liquid.

Przechowywanie i stabilność

Maintain at +2-8°C in undiluted aliquots for up to 6 months after date of receipt.

Informacje prawne

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
This page may contain text that has been machine translated.

Kod klasy składowania

10 - Combustible liquids

Klasa zagrożenia wodnego (WGK)

WGK 2

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable


Certyfikaty analizy (CoA)

Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.

Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Myelin gene regulatory factor is required for maintenance of myelin and mature oligodendrocyte identity in the adult CNS.
Koenning, M; Jackson, S; Hay, CM; Faux, C; Kilpatrick, TJ; Willingham, M; Emery, B
The Journal of Neuroscience null
Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord injury.
Keirstead, Hans S, et al.
The Journal of Neuroscience, 25, 4694-4705 (2005)
Na Wang et al.
Glia, 70(11), 2093-2107 (2022-07-02)
In humans, loss-of-function mutations of Kcnj10 in SeSAME/EAST syndrome, which encodes the inwardly rectifying K+ channel 4.1 (Kir 4.1), causes progressive neurological decline. Despite its rich expression in oligodendrocyte (OL) lineage cells and an emerging link with demyelinating disease, the
Kyohei Fujita et al.
The FEBS journal, 283(20), 3791-3806 (2016-10-21)
Neural crest-derived stem cells (NCSCs) are tissue-specific stem cells derived from multipotent neural crest cells. NCSCs are present in some adult tissues such as dorsal root ganglia, sciatic nerve, and bone marrow. However, little is known about the formation mechanisms
Liang Zhou et al.
eLife, 9 (2020-01-17)
Oligodendrocytes (OLs) myelinate axons and provide electrical insulation and trophic support for neurons in the central nervous system (CNS). Platelet-derived growth factor (PDGF) is critical for steady-state number and differentiation of oligodendrocyte precursor cells (OPCs), but its downstream targets are

Produkty

Human iPSC neural differentiation media and protocols used to generate neural stem cells, neurons and glial cell types.

Podłoża do różnicowania neuronalnego ludzkich iPSC i protokoły stosowane do generowania neuronalnych komórek macierzystych, neuronów i komórek glejowych.

Derivation and characterization of functional human neural stem cell derived oligodendrocyte progenitor cells (OPCs) that efficiently myelinate primary neurons in culture.

Uzyskanie i scharakteryzowanie funkcjonalnych komórek progenitorowych oligodendrocytów (OPC) pochodzących z ludzkich neuronalnych komórek macierzystych, które skutecznie mielinizują pierwotne neurony w hodowli.

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