393204

4-Hydroxynonenal

≥98% (HPLC), liquid, lipid peroxidation marker, Calbiochem^®

• Synonim(y): 4-Hydroxynonenal
• Wzór empiryczny (zapis Hilla): C₉H₁₆O₂
• Numer CAS: 75899-68-2
• Masa cząsteczkowa: 156.22
• Numer MDL: MFCD00211020
• Kod UNSPSC: 12352114
• NACRES: NA.77

Właściwości

• Nazwa produktu: 4-Hydroxynonenal, 4-Hydroxynonenal, CAS 75899-68-2, is a major aldehyde product formed by peroxidation of ω-6-unsaturated fatty acids that is regarded as a specific marker of lipid peroxidation.
• Poziom jakości: 100
• Próba: ≥98% (HPLC)
• Formularz: liquid
• producent / nazwa handlowa: Calbiochem^®
• warunki przechowywania: OK to freeze
• rozpuszczalność: ethanol: 10 mg/mL
• temp. przechowywania: −70°C
• ciąg SMILES: OC(CCCCC)\C=C\C=O
• InChI: 1S/C9H16O2/c1-2-3-4-6-9(11)7-5-8-10/h5,7-9,11H,2-4,6H2,1H3/b7-5+
• Klucz InChI: JVJFIQYAHPMBBX-FNORWQNLSA-N

Opis

Opis ogólny

4-Hydroxynonenal, CAS 75899-68-2, is a major aldehyde product formed by peroxidation of ω-6-unsaturated fatty acids that is regarded as a specific marker of lipid peroxidation.

A major aldehyde product formed by peroxidation of ω-6-unsaturated fatty acids that is regarded as a specific marker of lipid peroxidation. Inhibits proliferation and induces differentiation of HL-60 human leukemic cells. Also induces cell death in murine alveolar macrophages and in PC12 cells. An inhibitor of state 3 respiration at micromolar levels. Causes a transient increase in cytosolic Ca²⁺ and irreversibly inhibits Na⁺, K⁺-ATPase activity (IC₅₀ = 120 µM). Acts as a reversible inhibitor of c-Jun N-terminal kinase (JNK).

A major aldehydic product formed by peroxidation of ω-6-unsaturated fatty acids that is regarded as a specific marker of lipid peroxidation. Inhibits proliferation and induces differentiation of HL-60 human leukemic cells. Also induces cell death in murine alveolar macrophages. An inhibitor of State 3 respiration at micromolar levels that causes a transient increase in cytosolic Ca²⁺. Irreversibly inhibits Na⁺-K⁺-ATPase activity (IC₅₀ = 120 µM).

Działania biochem./fizjol.

Primary Target
Na⁺, K⁺-ATPase activity

Product does not compete with ATP.

Target IC₅₀: 120 µM against Na⁺, K⁺-ATPase activity

Ostrzeżenie

Toxicity: Flammable (J)

Postać fizyczna

Supplied at 10 mg/ml in ethanol

Rekonstytucja

Following initial thaw, aliquot and freeze (-70°C).

Inne uwagi

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Soh, Y., et al. 2000. Mol. Pharmacol.58, 535.
Carini, R., et al. 1996. Biochem. Biophys. Res. Commun.218, 772.
Li, L., et al. 1996. Toxicol.Appl. Pharmacol.139, 135.
Siems, W.G., et al. 1996. Free Radic. Res.20, 215.
Ullrich, O., et al. 1996. Free Radic. Res.24, 421.
van Kuijk, F.J., et al. 1995. Anal. Biochem. 224, 420.
Esterbauer, H., et al. 1991. Free Radic. Biol. Med.11, 81.

Informacje prawne

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS02,GHS07
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H225,H319
• Zwroty wskazujące środki ostrożności: P210 - P233 - P240 - P241 - P242 - P305 + P351 + P338
• Klasyfikacja zagrożeń: Eye Irrit. 2 - Flam. Liq. 2
• Kod klasy składowania: 3 - Flammable liquids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): 57.2 °F - closed cup
• Temperatura zapłonu (°C): 14 °C - closed cup