219675

CFTR Inhibitor II, GlyH-101

InSolution, ≥97%, potent, selective and reversible open-channel blocker of CFTR

• Synonim(y): InSolution CFTR Inhibitor II, GlyH-101, N-(2-Naphthalenyl)-((3,5-dibromo-2,4-dihydroxyphenyl)methylene)glycine hydrazide
• Wzór empiryczny (zapis Hilla): C₁₉H₁₅Br₂N₃O₃
• Numer CAS: 328541-79-3
• Masa cząsteczkowa: 493.15
• Kod UNSPSC: 12352200
• NACRES: NA.28

Właściwości

• Poziom jakości: 100
• Próba: ≥97% (HPLC)
• Formularz: liquid
• siła działania: 4.3 μM K_i
• producent / nazwa handlowa: Calbiochem^®
• warunki przechowywania: OK to freeze; avoid repeated freeze/thaw cycles; desiccated (hygroscopic); protect from light
• Warunki transportu: dry ice
• temp. przechowywania: −70°C
• InChI: 1S/C19H15Br2N3O3/c20-15-8-13(18(26)17(21)19(15)27)9-23-24-16(25)10-22-14-6-5-11-3-1-2-4-12(11)7-14/h1-9,22,26-27H,10H2,(H,24,25)/b23-9+
• Klucz InChI: RMBDLOATEPYBSI-NUGSKGIGSA-N

Opis

Opis ogólny

A cell-permeable glycinyl hydrazone compound that acts as a potent, selective and reversible open-channel blocker of CFTR with intermediate speed (<1 min; 95% inhibition at 50 µM; K_i = 4.3 µM in CFTR-expressing FRT cells for apical membrane Cl^- current) and exhibits desirable aqueous solubility. Shown to produce inwardly rectifying CFTR Cl^- currents with reduced mean channel open time and suggested to directly interact with the channel pore at the extracellular side of the membrane. Displays minimal effects on P-glycoprotein and non-CFTR-mediated Cl^- currents, and is effective in nasal and intestinal epithelia in vivo.

Działania biochem./fizjol.

Cell permeable: yes

Reversible: yes

Opakowanie

Packaged under inert gas

Ostrzeżenie

Toxicity: Irritant (B)

Postać fizyczna

A 25 mM (5 mg/406 µL) solution of CFTR Inhibitor II, GlyH-101 (Cat. No. 219671) in DMSO.

Rekonstytucja

Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 3 months at -70°C.

Informacje prawne

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 10 - Combustible liquids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): 188.6 °F - closed cup - (refers to pure substance)
• Temperatura zapłonu (°C): 87 °C - closed cup - (refers to pure substance)