203389
Blebbistatin, Racemic
≥97% (HPLC), liquid, Myosin II inhibitor, Calbiochem®
Synonim(y):
InSolutionBlebbistatin, Racemic
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About This Item
Wzór empiryczny (zapis Hilla):
C18H16N2O2
Masa cząsteczkowa:
292.33
Kod UNSPSC:
12352200
NACRES:
NA.77
Polecane produkty
product name
Blebbistatin, Racemic, InSolution, ≥97%, 50 mM in 90% DMSO, reversible inhibitor of nonmuscle myosin II
Poziom jakości
Próba
≥97% (HPLC)
Postać
liquid
producent / nazwa handlowa
Calbiochem®
warunki przechowywania
OK to freeze
desiccated (hygroscopic)
protect from light
Warunki transportu
wet ice
temp. przechowywania
−20°C
Opis ogólny
A cell-permeable compound that acts as a selective, potent, and reversible inhibitor of non-muscle myosin II. Inhibits the ATPase and gliding motility of human platelets (≤100 µM) without affecting myosin light chain kinase (MLCK) activity. Has been shown to block cell blebbing and to rapidly disrupt directed cell migration and cytokinesis in vertebrate cells. Does not disrupt mitosis or affect contractile ring assembly.
Działania biochem./fizjol.
Cell permeable: yes
Primary Target
ATPase
ATPase
Product does not compete with ATP.
Reversible: yes
Target IC50: <100 µM inhibiting the ATPase and gliding motility of human platelets
Opakowanie
Packaged under inert gas
Ostrzeżenie
Toxicity: Harmful & Carcinogenic / Teratogenic (E)
Postać fizyczna
A 50 mM (5 mg/342 µl) solution of (±)-Blebbistatin (Cat. No. 203390) in 90% DMSO.
Rekonstytucja
Following initial thaw, aliquot and freeze (-20°C).
Inne uwagi
Shu, S., et al. 2005. Proc. Natl. Acad. Sci. USA102, 1472.
Kovacs, M., et al. 2004. J. Biol. Chem.279, 35557.
Straight, A.F., et al. 2003. Science299, 1743.
Cheung, A., et al. 2001. Mol. Biol. Cell Suppl.12, 271a.
Kovacs, M., et al. 2004. J. Biol. Chem.279, 35557.
Straight, A.F., et al. 2003. Science299, 1743.
Cheung, A., et al. 2001. Mol. Biol. Cell Suppl.12, 271a.
Informacje prawne
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
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Kod klasy składowania
10 - Combustible liquids
Klasa zagrożenia wodnego (WGK)
WGK 1
Temperatura zapłonu (°F)
188.6 °F - closed cup - (Dimethylsulfoxide)
Temperatura zapłonu (°C)
87 °C - closed cup - (Dimethylsulfoxide)
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