19-137
Maślan sodu
For use as a histone deacetylase inhibitor.
Synonim(y):
Sól sodowa kwasu masłowego
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About This Item
Kod UNSPSC:
41116012
eCl@ss:
32160405
NACRES:
NA.41
Polecane produkty
Poziom jakości
Formularz
liquid
producent / nazwa handlowa
Upstate®
metody
activity assay: suitable (histone deacetylase (HDAC))
Warunki transportu
wet ice
Zastosowanie
Sodium Butyrate has been used:
- to inhibit histone deacetylase (HDAC) and study its effect on fibroblast growth factor 21 (FGF21) expression in liver
- to inhibit deacetylase activity in embryonic stem (ES) cells to determine if the enzymatic activity of the mSin3A-HDAC complex is essential for Nanog expression
- as a reagent during tissue homogenization
- as a supplement in chromatin immunoprecipitation (ChIP) dilution buffer
Działania biochem./fizjol.
Sodium Butyrate is a short-chain fatty acid and a histone deacetylase inhibitor. It protects dopaminergic neuronal cells from α-synuclein mediated transcriptional deregulation and DNA damage, maybe by enhancing the expression of DNA-repair genes. Sodium butyrate may promote the production of foreign proteins such as erythropoietin, tissue plasminogen activator, antibody, and nitric oxide synthase in recombinant Chinese hamster ovary (rCHO) cell cultures. But, the higher concentration of sodium butyrate in rCHO cell cultures may also exhibit a cytotoxic effect on cell growth by inducing apoptosis. Sodium Butyrate prevents the growth of cancer cells by downregulating the thioredoxin 1 (Trx1) expression, stimulating reactive oxygen species (ROS) production, and inhibiting cell proliferation and migration of various carcinoma cells including colorectal cancer (CRC).
Postać fizyczna
CH3CH2CH2COONa
Przechowywanie i stabilność
1 year at 4°C
Informacje prawne
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Hasło ostrzegawcze
Warning
Zwroty wskazujące rodzaj zagrożenia
Zwroty wskazujące środki ostrożności
Klasyfikacja zagrożeń
Eye Irrit. 2 - Skin Irrit. 2
Kod klasy składowania
12 - Non Combustible Liquids
Klasa zagrożenia wodnego (WGK)
WGK 1
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Certyfikaty analizy (CoA)
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