06-680-AF555

Anti-Androgen Receptor Antibody, Alexa Fluor^™ 555 Conjugate

from rabbit, ALEXA FLUOR^™ 555

• Synonim(y): Androgen receptor, Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4
• Kod UNSPSC: 12352203
• eCl@ss: 32160702

Właściwości

• pochodzenie biologiczne: rabbit
• Poziom jakości: 100
• białko sprzężone: ALEXA FLUOR^™ 555
• forma przeciwciała: affinity isolated antibody
• rodzaj przeciwciała: primary antibodies
• klon: polyclonal
• reaktywność gatunkowa: human, rat
• reaktywność gatunkowa (przewidywana na podstawie homologii): mouse (based on 100% sequence homology), canine (based on 100% sequence homology), horse (based on 100% sequence homology), bovine (based on 100% sequence homology)
• metody: immunocytochemistry: suitable
• numer dostępu NCBI: NP_036634
• numer dostępu UniProt: P15207
• docelowa modyfikacja potranslacyjna: unmodified
• informacje o genach: bovine ... Ar(280675) ; dog ... Ar(403588) ; human ... AR(367) ; mouse ... Ar(11835) ; rat ... Ar(24208)

Opis

Opis ogólny

Androgen receptor (UniProt P15207; also known as Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4) is encoded by the Ar (also known as Andr, Nr3c4, Tfm) gene (Gene ID 24208) in rat species. Androgen receptor (AR) is a hormone-activated transcription regulator that plays important roles in normal prostate development and function, as well as in malignant prostate transformation. The binding of an androgenic hormone (testosterone or dihydrotestosterone) induces a conformational change in AR, resulting in its dissociation from heat schock proteins and subsequent translocation from the cytosol to nucleus, where it dimerizes and mediates either transcription activation or repression in a target gene-specific manner. The androgen insensitivity syndrome (AIS) or testicular feminization (TFM) is caused by a mutation of the androgen receptor gene located on the X chromosome.

Immunogen

Epitope: N-terminal modulating region.

KLH-conjugated linear peptide corresponding to the N-terminal sequence of rat androgen receptor.

Zastosowanie

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Hormones & Receptors

The unconjugated antibody (Cat. No. 06-680) is shown to be suitable also for chromatin immunoprecipitation (ChIP), ChIP-seq, Western blotting, immunoprecipitation, flow cytometry, immunohistochemistry applications.

This Anti-Androgen Receptor Antibody, Alexa Fluor^™ 555 Conjugate is validated for use in Immunocytochemistry for the detection of Androgen Receptor.

Jakość

Evaluated by Immunocytochemistry in T47D cells.

Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected androgen receptor in T47D human breast cancer cells.

Opis wartości docelowych

~110 kDa observed.

Postać fizyczna

Affinity purified.

Purified rabbit polyclonal antibody conjugate in PBS with 15 mg/mL BSA and 0.1 % sodium azide.

Przechowywanie i stabilność

Stable for 1 year at 2-8°C from date of receipt.

Inne uwagi

Concentration: Please refer to lot specific datasheet.

Informacje prawne

ALEXA FLUOR is a trademark of Life Technologies

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 12 - Non Combustible Liquids
• Klasa zagrożenia wodnego (WGK): WGK 2
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable