B-067

(±)-Baclofen-D₄ solution

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

• Wzór empiryczny (zapis Hilla): C₁₀H₈D₄ClNO₂
• Masa cząsteczkowa: 217.69
• Numer MDL: MFCD21363459
• Kod UNSPSC: 41116107
• Identyfikator substancji w PubChem: 329773124
• NACRES: NA.24

Właściwości

• klasa czystości: certified reference material
• Poziom jakości: 300
• Postać: liquid
• Właściwości: Snap-N-Spike^®/Snap-N-Shoot^®
• opakowanie: ampule of 1 mL
• producent / nazwa handlowa: Cerilliant^®
• stężenie: 100 μg/mL in methanol
• metody: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• Zastosowanie: clinical testing
• format: single component solution
• temp. przechowywania: −20°C

Opis

Opis ogólny

Baclofen, a derivative of gamma-aminobutyric acid (GABA), is a muscle relaxant used to treat spasticity. Marketed with brand names such as Kemstro, Lioresal or Gablofen, the drug has also shown effectiveness in the treatment of alcoholism. This certified solution standard is suitable for use as an internal standard in quantitative mass spectrometry-based testing applications in clinical toxicology, forensic analysis, pharmaceutical research or diagnostic testing.

Zastosowanie

• Antidepressant Efficacy in Psychotherapy: Analyzes the effectiveness of combining antidepressants like O-Desmethylvenlafaxine with psychotherapy, enhancing therapeutic strategies for depression treatment (Alemi et al., 2024).


• Advanced Quantification Methods: Development of a multiplexed liquid chromatography-tandem mass spectrometry method for the quantification of Venlafaxine and its metabolites, including O-Desmethylvenlafaxine, crucial for precise pharmacokinetic studies in clinical settings (Pandey et al., 2024).


• Pharmacokinetic Modeling: Utilizes physiologically based pharmacokinetic modeling to explore the impact of CYP2D6 and CYP2C19 polymorphisms on Venlafaxine metabolism, crucial for understanding the role of O-Desmethylvenlafaxine in therapeutic efficacy and drug-gene interactions (Shen et al., 2024).


• Impact of Pharmacogenomics: Studies the influence of CYP2D6 phenotype on the pharmacokinetics of Venlafaxine in elderly patients, highlighting the importance of O-Desmethylvenlafaxine levels in optimizing antidepressant dosing (Men et al., 2024).


• Environmental Monitoring: Investigates the presence of pharmaceuticals, including O-Desmethylvenlafaxine, in surface waters under the EU Water Framework Directive, emphasizing the need for robust environmental surveillance and pollution control measures (Colzani et al., 2024).

Informacje prawne

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS02,GHS06,GHS08
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H225,H301 + H311 + H331,H370
• Zwroty wskazujące środki ostrożności: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• Klasyfikacja zagrożeń: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Organy docelowe: Eyes
• Kod klasy składowania: 3 - Flammable liquids
• Klasa zagrożenia wodnego (WGK): WGK 2
• Temperatura zapłonu (°F): 49.5 °F - closed cup
• Temperatura zapłonu (°C): 9.7 °C - closed cup