B-035

Buprenorphine glucuronide solution

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

• Synonim(y): Buprenorphine-3-β-D-glucuronide solution
• Wzór empiryczny (zapis Hilla): C₃₅H₄₉NO₁₀
• Numer CAS: 101224-22-0
• Masa cząsteczkowa: 643.76
• Numer WE: 200-659-6
• Numer MDL: MFCD08275541
• Kod UNSPSC: 41116107
• Identyfikator substancji w PubChem: 329773109
• NACRES: NA.24

Właściwości

• klasa czystości: certified reference material
• Poziom jakości: 300
• Postać: liquid
• Właściwości: SNAP-N-SPIKE^®, SNAP-N-SHOOT^®
• opakowanie: ampule of 1 mL
• producent / nazwa handlowa: Cerilliant^®
• drug control: Narcotic Licence Schedule A (Switzerland)
• stężenie: 100 μg/mL in methanol
• metody: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• Zastosowanie: clinical testing
• format: single component solution
• temp. przechowywania: −20°C
• ciąg SMILES: CO[C@]12CC[C@@]3(C[C@@H]1[C@](C)(O)C(C)(C)C)[C@H]4Cc5ccc(O[C@@H]6O[C@@H]([C@@H](O)[C@H](O)[C@H]6O)C(O)=O)c7O[C@@H]2[C@]3(CCN4CC8CC8)c57
• InChI: 1S/C35H49NO10/c1-31(2,3)32(4,42)20-15-33-10-11-35(20,43-5)30-34(33)12-13-36(16-17-6-7-17)21(33)14-18-8-9-19(26(46-30)22(18)34)44-29-25(39)23(37)24(38)27(45-29)28(40)41/h8-9,17,20-21,23-25,27,29-30,37-39,42H,6-7,10-16H2,1-5H3,(H,40,41)/t20-,21-,23+,24+,25-,27+,29-,30-,32+,33-,34+,35-/m1/s1
• Klucz InChI: CZULHKGIAJASAA-WWIHBJMFSA-N

Opis

Opis ogólny

Buprenorphine glucuronide is a major urinary metabolite of the semi-synthetic opioid, buprenorphine. This Certified Spiking Solution^® is suitable for use in LC/MS or GC/MS applications for clinical toxicology, forensic analysis, urine drug testing, or pain prescription monitoring. Buprenorphine is used for the management of moderate chronic pain and for the treatment of opioid addiction.

Zastosowanie

• Simplified processing and rapid quantification of buprenorphine, norbuprenorphine, and their conjugated metabolites in human plasma using UPLC-MS/MS: This study underscores the importance of buprenorphine glucuronide as a standard in pharmacokinetic research, facilitating accurate assessments of buprenorphine exposure during opioid use disorder treatment (Zhao et al., 2024).


• Quantitative Analysis of Buprenorphine, Norbuprenorphine, and Their Glucuronide Metabolites in Human Urine: Highlights the application of buprenorphine glucuronide in developing methods for analyzing opioid metabolites in urine, crucial for monitoring drug therapy and compliance in clinical settings (Gqamana et al., 2024).


• Interaction between buprenorphine and norbuprenorphine in neonatal opioid withdrawal syndrome: The research uses buprenorphine glucuronide to study drug interactions in treating neonatal opioid withdrawal, demonstrating its significance in neonatal pharmacological research and therapy optimization (Tobacyk et al., 2023).

Informacje prawne

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS02,GHS06,GHS08
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H225,H301 + H311 + H331,H370
• Zwroty wskazujące środki ostrożności: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• Klasyfikacja zagrożeń: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Organy docelowe: Eyes
• Kod klasy składowania: 3 - Flammable liquids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): 49.5 °F - closed cup
• Temperatura zapłonu (°C): 9.7 °C - closed cup