700047P

5α,6α-epoxycholestanol-d7

Avanti Polar Lipids

• Synonim(y): cholestanol, 5α,6α-epoxy-d7
• Wzór empiryczny (zapis Hilla): C₂₇H₃₉O₂D₇
• Numer CAS: 127685-38-5
• Masa cząsteczkowa: 409.70
• Kod UNSPSC: 12352100
• NACRES: NA.25

Właściwości

• Próba: >99% (TLC)
• Postać: powder
• opakowanie: pkg of 1 × 1 mg (700047P-1mg)
• producent / nazwa handlowa: Avanti Polar Lipids
• Warunki transportu: dry ice
• temp. przechowywania: −20°C

Opis

Opis ogólny

5α,6α-epoxycholestanol (5α,6α-EC) is generated by cholesterol epoxidation. 5α,6α-epoxycholestanol-d7 is a deuterated derivative of 5α,6α-EC. It is catabolized by the enzyme cholesterol-5,6-epoxide hydrolase (ChEH) enzyme to 3β,5α,6β-triol.

Zastosowanie

5α,6α-epoxycholestanol-d7 has been used as an internal standard in isotope dilution-mass spectrometry analysis of heart mitochondrial samples. It may be used as an internal standard in liquid chromatography with tandem mass spectrometry (LC-MS-MS) analysis of plasma samples.

Działania biochem./fizjol.

5α,6α-epoxycholestanol (5α,6α-EC) is a liver X receptor (LXR) antagonist. 5α,6α-EC is employed in anticancer treatments. It impairs redox state and affects atherogenesis. The levels of 5α,6α-EC are elevated in hypercholesterolemia. It mediates steroid receptor coactivator (SRC) recruitment.

Opakowanie

5 mL Amber Glass Screw Cap Vial (700047P-1mg)

Informacje prawne

Avanti Research is a trademark of Avanti Polar Lipids, LLC

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids