QBD10763

t-Boc-N-amido-dPEG^®₂₄-acid

>95% (HPLC)

• Synonim(y): t-Boc-N-amido-PEG₂₄-COOH, t-Boc-N-amido-PEG₂₄-acid, t-Boc-PEG-acid, BocNH-PEG₁₀₀₀-acid, BocNH-​PEG₂₄-​CH₂CH₂COOH
• Wzór empiryczny (zapis Hilla): C₅₆H₁₁₁NO₂₈
• Masa cząsteczkowa: 1246.47
• Numer MDL: MFCD21363324
• Kod UNSPSC: 12352106
• NACRES: NA.22

Właściwości

• Próba: >95% (HPLC)
• Formularz: solid or viscous liquid
• przydatność reakcji: reaction type: Pegylations
• architektura polimerowa: shape: linear; functionality: heterobifunctional
• Warunki transportu: ambient
• temp. przechowywania: −20°C

Opis

Cechy i korzyści

t-Boc-N-amido-dPEG₂₄-acid is a monodisperse PEG product that is useful for peptide synthesis. The 76-atoms-long dPEG spacer allows the introduction of a long, hydrophilic spacer onto either end of a peptide chain or on an amino acid side chain. The flexible dPEG spacer conjugates to peptides using conventional peptide synthesis chemistry. The Boc protecting group removes easily with acids such as trifluoroacetic acid (TFA), HF, and trifluoromethane sulfonic acid (TFMSA). Peptide PEGylation imparts water solubility to hydrophobic peptide chains, expands the PEG-peptide conjugates′ hydrodynamic volumes (thus decreasing renal clearance), and protects PEGylated peptides from proteolysis. The combination of decreased renal clearance and protection from proteolysis contributes to longer in vivo circulation times for PEGylated (as compared to non-PEGylated) peptides. Additionally, PEGylation diminishes a peptide′s antigenicity. This product is part of the t-Boc-N-amido-dPEG_n-acid (n=4, 8, 12, 24, 36) product series.

Informacje prawne

Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681

dPEG is a registered trademark of Quanta BioDesign

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable