934291

Thalidomide-O-amido-C₈-NH₂ trifluoroacetate

≥95.0%

• Synonim(y): N-(8-Aminooctyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide trifluoroacetate
• Wzór empiryczny (zapis Hilla): C₂₃H₃₀N₄O₆·C₂HF₃O₂
• Numer CAS: 1950635-16-1
• Masa cząsteczkowa: 572.53
• Kod UNSPSC: 12352200
• NACRES: NA.21

Właściwości

• ligand: thalidomide
• Poziom jakości: 100
• Próba: ≥95.0%
• Postać: powder or crystals
• temp. przechowywania: 2-8°C
• ciąg SMILES: O=C(C(F)(F)F)[O-].O=C(COC1=CC=CC(C(N2C3C(NC(CC3)=O)=O)=O)=C1C2=O)NCCCCCCCC[NH3+]

Opis

Zastosowanie

A functionalized cereblon ligand for development of Thalidomide based PROTACs. Allows rapid conjugation with carboxyl linkers due to presence of amine group via peptide coupling reactions. Amenable for linker attachement via reductive amination, and a basic building block for making protein degrader library.

Technology Spotlight:

Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks

Inne uwagi

Targeted Protein Degradation by Small Molecules

Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

Informacje prawne

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS06,GHS08
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H301,H312,H360D
• Zwroty wskazujące środki ostrożności: P202 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P362 + P364
• Klasyfikacja zagrożeń: Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Repr. 1A
• Kod klasy składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable