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Merck

SCN2A

sodium channel, voltage-gated, type II, alpha subunit

Synonimy:
BFIC3, BFIS3, BFNIS, EIEE11, HBA, HBSCI, HBSCII, NAC2, Na(v)1.2, Nav1.2, SCN2A1, SCN2A2
Gatunek:
Identyfikator UniProtKB:
Identyfikator genu:
  • Human(6326) Summary: Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. It is heterogeneously expressed in the brain, and mutations in this gene have been linked to several seizure disorders. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
  • chicken(395945) sodium channel, voltage-gated, type II, alpha subunit
  • dog(478773) sodium channel, voltage-gated, type II, alpha subunit
  • Horse(100051816) sodium channel, voltage-gated, type II, alpha subunit
  • domestic cat(101080472) sodium channel, voltage-gated, type II, alpha subunit
  • domestic guinea pig(100716680) sodium channel, voltage-gated, type II, alpha subunit
  • naked mole-rat(101715020) sodium channel, voltage-gated, type II, alpha subunit
  • cow(539718) sodium channel, voltage-gated, type II, alpha subunit
  • sheep(101103126) sodium channel, voltage-gated, type II, alpha subunit

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Small Molecule - Antagonist

Numer produktu
Opis
Gatunek
Riluzole, solid,
Gatunek
rat, human
Oxcarbazepine, ≥98% (HPLC), solid,
Gatunek
rat, human
BIA 2-093, ≥98% (HPLC), solid,
Gatunek
rat, human
Lidocaine, analytical standard,
Gatunek
rat, human
Lidocaine, powder,
Gatunek
rat, human

Antibodies

Numer produktu
Opis
Reaktywność gatunkowa
Zastosowanie
Anti-SCN2A Antibody, clone 5H10.2, clone 5H10.2, from mouse,
Reaktywność gatunkowa
human
Zastosowanie
western blot
Anti-Sodium Channel Antibody, Voltage Gated, Brain Type II, Chemicon®, from rabbit,
Reaktywność gatunkowa
mouse, rat
Zastosowanie
immunohistochemistry
western blot
Anti-SODIUM CHANNEL-PAN antibody produced in rabbit, affinity isolated antibody,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
ELISA
immunohistochemistry

western blot
Monoclonal Anti-Sodium Channel, Pan antibody produced in mouse, ~1 mg/mL, clone K58/35, purified immunoglobulin,
Reaktywność gatunkowa
mammals
Zastosowanie
immunofluorescence
immunohistochemistry

western blot

Small Molecule - Blocker

Numer produktu
Opis
Gatunek
Rufinamide, ≥98% (HPLC), powder,
Gatunek
human
Lidocaine, Pharmaceutical Secondary Standard; Certified Reference Material,
Gatunek
human
Carbamazepine, Pharmaceutical Secondary Standard; Certified Reference Material,
Gatunek
human
Procaine hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material,
Gatunek
human
Tetracaine hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material,
Gatunek
human

esiRNA

Numer produktu
Opis
Gatunek
MISSION® esiRNA, targeting mouse Scn2a,
Gatunek
mouse
MISSION® esiRNA, targeting human SCN2A,
Gatunek
human