S8809

Monoclonal Anti-Sodium Channel, Pan antibody produced in mouse

~1 mg/mL, clone K58/35, purified immunoglobulin

• Synonim(y): Przeciwciało kanału sodowego
• Numer MDL: MFCD02097413
• Kod UNSPSC: 12352203
• NACRES: NA.41

Właściwości

• pochodzenie biologiczne: mouse
• Poziom jakości: 200
• białko sprzężone: unconjugated
• forma przeciwciała: purified immunoglobulin
• rodzaj przeciwciała: primary antibodies
• klon: K58/35, monoclonal
• reaktywność gatunkowa: mammals
• stężenie: ~1 mg/mL
• metody: immunohistochemistry (frozen sections): suitable; indirect immunofluorescence: 1 μg/mL using sciatic and optic nerve sections; cultured hypocampal neurons; western blot: 1 μg/mL using crude brain membrane prep (rat)
• izotyp: IgG1
• numer dostępu UniProt: P35498
• Warunki transportu: wet ice
• temp. przechowywania: −20°C
• informacje o genach: human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN8A(6334) , SCN9A(6335) ; mouse ... Scn10a(20264) , Scn11a(24046) , Scn1a(20265) , Scn3a(20269) , Scn4a(110880) , Scn5a(20271) , Scn8a(20273) , Scn9a(20274) ; rat ... Scn10a(29571) , Scn11a(29701) , Scn1a(81574) , Scn3a(497770) , Scn4a(25722) , Scn5a(25665) , Scn8a(29710) , Scn9a(78956)

Opis

Opis ogólny

Voltage-gated sodium channels/VGSCs (Nav) are transmembrane proteins that are initiated by the depolarization of the membrane. They are heteromultimers with large pore-forming α-subunits and smaller β-subunits.

Specyficzność

The sequence recognized by this clone is identical in all known vertebrate Na⁺ channels. In cultured hippocampal neurons, the antibody specifically stains the axon initial segment. In sciatic and optic nerves, it stains the nodes of Ranvier.

Immunogen

synthetic peptide CTEEQKKYYNAMKKLGSKK from the intracellular III-IV loop of Na⁺ channels

Zastosowanie

Monoclonal Anti-Sodium Channel, Pan antibody produced in mouse has been used in:

• immunohistochemistry(1:50)
• immunostaining (1:200)
• immunofluorescence
• immunocytochemistry (1:100)

Działania biochem./fizjol.

Voltage-gated sodium channels/VGSCs (Nav) participates in nociceptive transmission. They play a key role in regulating the exchange between the extracellular and intracellular spaces. VGSCs are crucial for the initiation and firing of action potentials. They participate in neuronal excitability. Hence mutations in the VGSC genes results in several epileptic disorders.

Postać fizyczna

Solution in 10 mM Tris, pH 7.5, containing 0.1 m NaCl, 30% glycerol, and 15 mM sodium azide.

Informacje prawne

Sold under exclusive license from SUNY Stony Brook.

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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