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Merck

SCN1A

sodium channel, voltage-gated, type I, alpha subunit

Synonimy:
EIEE6, FEB3, FEB3A, FHM3, GEFSP2, HBSCI, NAC1, Nav1.1, SCN1, SMEI
Gatunek:
Identyfikator UniProtKB:
Identyfikator genu:
  • Human(6323) Summary: The vertebrate sodium channel is a voltage-gated ion channel essential for the generation and propagation of action potentials, mainly in nerve and muscle. Voltage-sensitive sodium channels are heteromeric complexes consisting of a large central pore-forming glycosylated alpha subunit, and two smaller auxiliary beta subunits. This gene encodes the large alpha subunit, and mutations in this gene have been associated with several epilepsy, convulsion and migraine disorders. Alternative splicing results in multiple transcript variants. The RefSeq Project has decided to create four representative RefSeq records. Three of the transcript variants are supported by experimental evidence and the fourth contains alternate 5' untranslated exons, the exact combination of which have not been experimentally confirmed for the full-length transcript.[provided by RefSeq, Jan 2011]
  • Mouse(20265) sodium channel, voltage-gated, type I, alpha
  • Rat(81574) sodium channel, voltage-gated, type I, alpha
  • Zebrafish(393101) sodium channel, voltage-gated, type I, alpha
  • Zebrafish(100536219) sodium channel, voltage-gated, type I, alpha subunit
  • dog(478775) sodium channel, voltage-gated, type I, alpha subunit
  • domestic cat(101081823) sodium channel, voltage-gated, type I, alpha subunit
  • Horse(100052059) sodium channel, voltage-gated, type I, alpha subunit
  • chicken(771555) sodium channel, voltage-gated, type I, alpha subunit
  • domestic guinea pig(100715839) sodium channel, voltage-gated, type I, alpha subunit
  • Domestic Rabbit(100009591) sodium channel, voltage-gated, type I, alpha subunit
  • naked mole-rat(101710495) sodium channel, voltage-gated, type I, alpha subunit
  • cow(529590) sodium channel, voltage-gated, type I, alpha subunit
  • sheep(101123531) sodium channel, voltage-gated, type I, alpha subunit

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Small Molecule - Antagonist

Numer produktu
Opis
Gatunek
Riluzole, solid,
Gatunek
rat, human
Oxcarbazepine, ≥98% (HPLC), solid,
Gatunek
rat, human
BIA 2-093, ≥98% (HPLC), solid,
Gatunek
rat, human
Lidocaine, analytical standard,
Gatunek
rat, human
Lidocaine, powder,
Gatunek
rat, human

Antibodies

Numer produktu
Opis
Reaktywność gatunkowa
Zastosowanie
Anti-Sodium Channel Antibody, Voltage Gated, Brain Type I, Chemicon®, from rabbit,
Reaktywność gatunkowa
mouse, rat
Zastosowanie
immunohistochemistry
western blot
Anti-Sodium Channel, Pan antibody produced in rabbit, affinity isolated antibody, lyophilized powder,
Reaktywność gatunkowa
rat
Zastosowanie
immunohistochemistry
immunoprecipitation (IP)

western blot
Anti-Sodium Channel Antibody, Voltage Gated, Pan (SP19 Segment), Chemicon®, from rabbit,
Reaktywność gatunkowa
mouse, rat
Zastosowanie
immunohistochemistry
western blot
Anti-Sodium Channel, Brain Type I (α subunit) antibody produced in rabbit, affinity isolated antibody, lyophilized powder,
Reaktywność gatunkowa
mouse, rat
Zastosowanie
immunohistochemistry
western blot
Monoclonal Anti-Sodium Channel, Pan antibody produced in mouse, ~1 mg/mL, clone K58/35, purified immunoglobulin,
Reaktywność gatunkowa
mammals
Zastosowanie
immunofluorescence
immunohistochemistry

western blot

Small Molecule - Blocker

Numer produktu
Opis
Gatunek
Rufinamide, ≥98% (HPLC), powder,
Gatunek
human
Lidocaine, Pharmaceutical Secondary Standard; Certified Reference Material,
Gatunek
human
Carbamazepine, Pharmaceutical Secondary Standard; Certified Reference Material,
Gatunek
human
Procaine hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material,
Gatunek
human
Tetracaine hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material,
Gatunek
human

Small Molecule - Inhibitor

Numer produktu
Opis
Gatunek
Lidocaine, analytical standard,
Gatunek
rat, human
Lidocaine, powder,
Gatunek
rat, human
Propafenone hydrochloride, ,
Gatunek
human
5,5-Diphenylhydantoin, ≥98%,
Gatunek
human, rat
5,5-Diphenylhydantoin sodium salt, ≥99%,
Gatunek
human, rat

esiRNA

Numer produktu
Opis
Gatunek
MISSION® esiRNA, targeting human SCN1A,
Gatunek
human
MISSION® esiRNA, targeting mouse Scn1a,
Gatunek
mouse