1445200

Mitoxantrone hydrochloride

United States Pharmacopeia (USP) Reference Standard

• 동의어(들): Mitoxantrone dihydrochloride, 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione dihydrochloride
• 실험식(Hill 표기법): C₂₂H₂₈N₄O₆ · 2HCl
• CAS Number: 70476-82-3
• Molecular Weight: 517.40
• MDL number: MFCD00242943
• UNSPSC 코드: 41116107
• PubChem Substance ID: 329750478
• NACRES: NA.24

속성

• Grade: pharmaceutical primary standard
• API family: mitoxantrone
• 제조업체/상표: USP
• 응용 분야: pharmaceutical (small molecule)
• 형식: neat
• SMILES string: Cl[H].Cl[H].OCCNCCNc1ccc(NCCNCCO)c2C(=O)c3c(O)ccc(O)c3C(=O)c12
• InChI: 1S/C22H28N4O6.2ClH/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32;;/h1-4,23-30H,5-12H2;2*1H
• InChI key: ZAHQPTJLOCWVPG-UHFFFAOYSA-N
• 유전자 정보: human ... TOP2A(7153)

설명

일반 설명

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

애플리케이션

Mitoxantrone hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

• Mitoxantrone Injection

생화학적/생리학적 작용

Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. Mitoxantrone also displays broad immunosuppressive activity inhibiting proliferation of all classes of lymphocytes and inducing apoptosis of antigen-presenting T cells. It used clinically as a chemotherapeutic agent against leukemias and solid tumors and as an immune system modulator in multiple sclerosis.

분석 메모

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

기타 정보

Sales restrictions may apply.

안전성 정보

• 픽토그램: GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H340,H360
• 예방조치 성명서: P201 - P280 - P308 + P313
• Hazard Classifications: Muta. 1B - Repr. 1B
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable