T3455

Terameprocol

≥98% (HPLC)

• 동의어(들): 2,3-Dimethyl-1,4-bis-(3,4-dimethoxyphenyl)butane, EM-1421, M4N, TMNDGA, Tetra-O-methyl nordihydroguaiaretic acid, rel-4-[(2R,3S)-4-(3,4-Dimethoxyphenyl)-2,3-dimethylbutyl]-1,2-dimethoxybenzene, tetra-O-methyl-NDGA, tetramethyl NDGA, tetramethyl Nordihydroguaiaretic Acid
• 실험식(Hill 표기법): C₂₂H₃₀O₄
• CAS Number: 24150-24-1
• Molecular Weight: 358.47
• MDL number: MFCD11113155
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329826768
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 형태: powder
• 색상: white to off-white
• solubility: DMSO: ≥10 mg/mL
• 저장 온도: −20°C
• SMILES string: COc1ccc(C[C@H](C)[C@H](C)Cc2ccc(OC)c(OC)c2)cc1OC
• InChI: 1S/C22H30O4/c1-15(11-17-7-9-19(23-3)21(13-17)25-5)16(2)12-18-8-10-20(24-4)22(14-18)26-6/h7-10,13-16H,11-12H2,1-6H3/t15-,16+
• InChI key: ORQFDHFZSMXRLM-IYBDPMFKSA-N

설명

생화학적/생리학적 작용

Terameprocol is a synthetic derivative of NDGA, a non-selective lipoxygenase inhibitor. It inhibits Sp1 transcription factor binding at the HIV long terminal repeat promoter and at the α-ICP4 promoter, a gene essential for HSV replication, with IC50 values of 11 and 43.5 μM respectively. TMNDGA induces growth arrest and apoptosis by suppressing Sp1-dependent Cdc2 and survivin gene expression giving rise to its antitumorigenic activity. The in vivo growth of xenografts in numerous human tumor types was suppressed upon treatment with TMNDGA It also inhibits the growth of murine and human melanomas and human colon cancer in vivo without causing other tissue toxicity.

Terameprocol is known to reduce angiogenesis¹.

제조 메모

Terameprocol is soluble in DMSO at a concentration that is greater than or equal to 10 mg/ml.

안전성 정보

• 픽토그램: GHS09
• 신호어: Warning
• 유해 및 위험 성명서: H410
• 예방조치 성명서: P273 - P391 - P501
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable