추천 제품
생물학적 소스
human
재조합
expressed in E. coli
분석
≥95% (SDS-PAGE)
양식
liquid
분자량
46.6 kDa (418aa)
포장
pkg of 100 μg
NCBI 수납 번호
배송 상태
dry ice
저장 온도
−70°C
유전자 정보
human ... PPM1A(5494)
일반 설명
Protein phosphatase 2C-α (PP2C-α), also referred to as protein phosphatase, Mg2+/Mn2+ dependent 1A (PPM1A), is encoded by the gene mapped to human chromosome 4q12. The encoded protein belongs to the family of Ser/Thr protein phosphatases. It is characterized with a catalytic subunit and a constant regulatory subunit. PP2C-α is abundantly expressed in heart and skeletal muscle.
생화학적/생리학적 작용
Protein phosphatase 2C-α (PP2C-α) is known to be a negative regulator of cell stress response pathways. Additionally, it has been reported to negatively regulate transforming growth factor-β (TGF-β) signaling pathway and cell cycle. PP2C-α has been shown to dephosphorylate cyclin-dependent kinases (CDKs) and it may be involved in cell cycle control. It modulates cell migration and invasion.
서열
MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWILMGAF LDKPKMEKHN AQGQGNGLRY GLSSMQGWRV EMEDAHTAVI GLPSGLESWS FFAVYDGHAG SQVAKYCCEH LLDHITNNQD FKGSAGAPSV ENVKNGIRTG FLEIDEHMRV MSEKKHGADR SGSTAVGVLI SPQHTYFINC GDSRGLLCRN RKVHFFTQDH KPSNPLEKER IQNAGGSVMI QRVNGSLAVS RALGDFDYKC VHGKGPTEQL VSPEPEVHDI ERSEEDDQFI ILACDGIWDV MGNEELCDFV RSRLEVTDDL EKVCNEVVDT CLYKGSRDNM SVILICFPNA PKVSPEAVKK EAELDKYLEC RVEEIIKKQG EGVPDLVHVM RTLASENIPS LPPGGELASK RNVIEAVYNR LNPYKNDDTD STSTDDMW
물리적 형태
1 mg/mL solution in 10 mM Tris-HCl, pH 7.5, 50 mM NaCl, 2 mM DTT, 1 mM MnCl2, 20% glycerol.
제조 메모
Centrifuge the vial prior to opening.
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Eye Irrit. 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Loss of PPM1A expression enhances invasion and the epithelial-to-mesenchymal transition in bladder cancer by activating the TGF-β/Smad signaling pathway.
Geng J, et al.
Oncotarget, 5(14), 5700-5711 (2014)
Integrated analysis of expression and genome alteration reveals putative amplified target genes in esophageal cancer.
Takashi S, et al.
Oncology Letters, 18(2), 465-472 (2007)
PPM1A Methylation Is Associated With Vascular Recurrence in Aspirin-Treated Patients.
Gallego-Fabrega C, et al.
Stroke, 47(7), 1926-1929 (2016)
Dephosphorylation of human cyclin-dependent kinases by protein phosphatase type 2Cα and β2 isoforms.
Cheng A, et al.
The Journal of Biological Chemistry, 275(44), 34744-34749 (2000)
Conformational Changes in Active and Inactive States of Human PP2Cα Characterized by Hydrogen/Deuterium Exchange-Mass Spectrometry.
Mazur S J, et al.
Biochemistry, 56(21), 2676-2689 (2017)
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