추천 제품
생물학적 소스
human
재조합
expressed in baculovirus infected Sf9 cells
분석
≥70% (SDS-PAGE)
양식
buffered aqueous glycerol solution
특이 활성도
960-1440 nmol/min·mg
분자량
~105 kDa
NCBI 수납 번호
응용 분야
cell analysis
배송 상태
dry ice
저장 온도
−70°C
유전자 정보
human ... PPM1A(5494)
일반 설명
Protein phosphatase 2C-α (PP2C-α), also called protein phosphatase, Mg2+/Mn2+ dependent 1A (PPM1A), is a member of the family of Ser/Thr protein phosphatases and is composed of a catalytic subunit and a constant regulatory subunit. PP2C-α is highly expressed in heart and skeletal muscle. The gene encoding this protein is localized on human chromosome 4q12.
생화학적/생리학적 작용
Protein phosphatase 2C-α (PP2C-α) or PPM1A is known to be negative regulators of cell stress response pathways. It has been reported to negatively regulate TGF-β signaling pathway and cell cycle. PP2C-α has been shown to dephosphorylate cyclin-dependent kinases (CDKs) and it may be involved in cell cycle control. It modulates cell migration and invasion. Overexpression of PP2C-α is reported to cause cell-growth arrest or cell death.
물리적 형태
Supplied in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
제조 메모
After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles.
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Dephosphorylation of Human Cyclin-dependent Kinases by Protein Phosphatase Type 2Ca and ?2 Isoforms*
Aiyang Cheng
The Journal of Biological Chemistry (2000)
Conformational Changes in Active and Inactive States of Human PP2Ca Characterized by Hydrogen/Deuterium Exchange-Mass Spectrometry.
Mazur SJ
Biochemistry (2017)
PPM1A Methylation Is Associated With Vascular Recurrence in Aspirin-Treated Patients.
Gallego-Fabrega C
Stroke (2016)
The cloning expression and tissue distribution of human PP2C?1
Anna E.Marley
Febs Letters (1998)
Loss of PPM1A expression enhances invasion and the epithelial-to-mesenchymal transition in bladder cancer by activating the TGF-?/Smad signaling pathway.
Geng J
Oncotarget (2014)
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