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Merck
모든 사진(2)

주요 문서

SRP5335

Sigma-Aldrich

PP2C-α, active, GST tagged human

recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

동의어(들):

FLJ42306, MGC9201, PP2C-ALPHA, PP2CA, PPM1A

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About This Item

CAS Number:
UNSPSC 코드:
12352200
NACRES:
NA.32

생물학적 소스

human

재조합

expressed in baculovirus infected Sf9 cells

분석

≥70% (SDS-PAGE)

양식

buffered aqueous glycerol solution

특이 활성도

960-1440 nmol/min·mg

분자량

~105 kDa

NCBI 수납 번호

응용 분야

cell analysis

배송 상태

dry ice

저장 온도

−70°C

유전자 정보

human ... PPM1A(5494)

일반 설명

Protein phosphatase 2C-α (PP2C-α), also called protein phosphatase, Mg2+/Mn2+ dependent 1A (PPM1A), is a member of the family of Ser/Thr protein phosphatases and is composed of a catalytic subunit and a constant regulatory subunit. PP2C-α is highly expressed in heart and skeletal muscle. The gene encoding this protein is localized on human chromosome 4q12.

생화학적/생리학적 작용

Protein phosphatase 2C-α (PP2C-α) or PPM1A is known to be negative regulators of cell stress response pathways. It has been reported to negatively regulate TGF-β signaling pathway and cell cycle. PP2C-α has been shown to dephosphorylate cyclin-dependent kinases (CDKs) and it may be involved in cell cycle control. It modulates cell migration and invasion. Overexpression of PP2C-α is reported to cause cell-growth arrest or cell death.

물리적 형태

Supplied in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.

제조 메모

After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Dephosphorylation of Human Cyclin-dependent Kinases by Protein Phosphatase Type 2Ca and ?2 Isoforms*
Aiyang Cheng
The Journal of Biological Chemistry (2000)
Conformational Changes in Active and Inactive States of Human PP2Ca Characterized by Hydrogen/Deuterium Exchange-Mass Spectrometry.
Mazur SJ
Biochemistry (2017)
PPM1A Methylation Is Associated With Vascular Recurrence in Aspirin-Treated Patients.
Gallego-Fabrega C
Stroke (2016)
The cloning expression and tissue distribution of human PP2C?1
Anna E.Marley
Febs Letters (1998)
Loss of PPM1A expression enhances invasion and the epithelial-to-mesenchymal transition in bladder cancer by activating the TGF-?/Smad signaling pathway.
Geng J
Oncotarget (2014)

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