P6993

Protein Phosphatase 2A₁ bovine

≥1500 units/mg protein

• 동의어(들): PPA2A₁
• MDL number: MFCD00241719
• UNSPSC 코드: 12352204
• NACRES: NA.54

속성

• 생물학적 소스: bovine
• Quality Level: 200
• 분석: ≥90% (SDS-PAGE)
• 형태: solution
• 특이 활성도: ≥1500 units/mg protein
• 분자량: 192 kDa
• 포장: vial of 1 μg
• 배송 상태: dry ice
• 저장 온도: −70°C

설명

일반 설명

Protein Phosphatase 2A1 (PP2A1) belongs to the PP2A family and comprises trimeric A, B and C subunits. PPA2 enzymes are serine/threonine phosphatases and exist as several isoforms.

애플리케이션

Protein phosphatase 2A₁ has been used to treat human fibroblast cells prior to western blot analysis.

생화학적/생리학적 작용

Protein Phosphatase 2A is a cytoplasmic protein, which colocalizes with microtubule proteins and is involved in the dephosphorylation of the tau protein and oncoprotein 18. Protein Phosphatase 2A1 (PP2A1) binds to polymerized microtubule proteins and may be targeted by tubulin in modulating phosphatase activity. PP2A1 is implicated as a growth suppressor and is associated with dysregulation in cancer. It also regulates cell cycle, RNA splicing differentiation, and signal transduction. PP2A dysfunction is correlated to the tau protein deregulation in Alzheimer′s disease pathophysiology. Protein Phosphatase 2A1 is a divalent cation-dependent protein serine/threonine phosphatase implicated as a growth suppressor and is associated with dysregulation in cancer.

단위 정의

One unit will release 1.0 nanomole of phosphate from ³²P-labeled phosphorylase A per minute at pH 7.0 at 30 °C.

물리적 형태

Solution in 50 mM Tris-HCl, pH 7.0, containing 14 mM 2-mercaptoethanol, 1 mM benzamidine, 0.1 mM PMSF, 1 mM EDTA, and 50% glycerol

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H317
• 예방조치 성명서: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Hazard Classifications: Skin Sens. 1
• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable