SML0720

Methazolamide

≥98% (HPLC)

• 동의어(들): 5-Acetylimino-4-methyl-·2-1,3,4-thiadiazoline-2-sulfonamide, N-(4-Methyl-2-sulfamoyl-Δ²-1,3,4-thiadiazolin-5-ylidene) acetamide, L 584601, N-[5-(Aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide
• 실험식(Hill 표기법): C₅H₈N₄O₃S₂
• CAS Number: 554-57-4
• Molecular Weight: 236.27
• EC Number: 209-066-7
• MDL number: MFCD00083416
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329825590
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 저장 조건: protect from light
• 색상: white to beige
• mp: 208 °C (dec.) (lit.)
• solubility: DMSO: 20 mg/mL, clear
• 저장 온도: 2-8°C
• SMILES string: CN1N=C(S\C1=N\C(C)=O)S(N)(=O)=O
• InChI: 1S/C5H8N4O3S2/c1-3(10)7-4-9(2)8-5(13-4)14(6,11)12/h1-2H3,(H2,6,11,12)/b7-4+
• InChI key: FLOSMHQXBMRNHR-QPJJXVBHSA-N
• 유전자 정보: human ... CA1(759) , CA2(760) , CA4(762) , CA7(766)

설명

생화학적/생리학적 작용

Cell-permeable and potent carbonic anhydrase (CA) inhibitor

Methazolamide has a plasma half-life of 14 hours in humans. Methazolamide has relatively good lipid solubility and low plasma protein binding ability. Thus, it diffuses into tissues and fluids much more readily than acetazolamide, another carbonic anhydrase inhibitor. Methazolamide has less side effects than acetazolamide.

Methazolamide is a cell-permeable and potent carbonic anhydrase (CA) inhibitor that is used in the treatment of glaucoma. Methazolamide is an insulin sensitizer that reduces hepatic glucose generation in animal models.

기타 정보

Light sensitive

안전성 정보

• 픽토그램: GHS08,GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302 + H312 + H332,H351
• 예방조치 성명서: P202 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3