F4381

Furosemide

≥98% (HPLC), powder, NKCC symporter inhibitor

• 동의어(들): 4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid, 5-(Aminosulfonyl)-4-chloro-2-([2-furanylmethyl]amino)benzoic acid
• 실험식(Hill 표기법): C₁₂H₁₁ClN₂O₅S
• CAS Number: 54-31-9
• Molecular Weight: 330.74
• EC Number: 200-203-6
• MDL number: MFCD00010549
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24277714
• NACRES: NA.77

속성

• product name: Furosemide,
• 생물학적 소스: synthetic (organic)
• 분석: ≥98% (HPLC)
• 형태: powder
• mp: 220 °C (dec.) (lit.)
• solubility: acetone: 50 mg/mL, clear to slightly hazy, colorless to yellow
• 주관자: Sanofi Aventis
• 저장 온도: room temp
• SMILES string: NS(=O)(=O)c1cc(C(O)=O)c(NCc2ccco2)cc1Cl
• InChI: 1S/C12H11ClN2O5S/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h1-5,15H,6H2,(H,16,17)(H2,14,18,19)
• InChI key: ZZUFCTLCJUWOSV-UHFFFAOYSA-N
• 유전자 정보: human ... ALB(213) , CYP1A2(1544) , SLC12A1(6557)

설명

일반 설명

Furosemide is a an ototoxic high-ceiling diuretic.

애플리케이션

Furosemide has been used:

• to investigate the influence of timing of dexamethasone administration on auditory hair cell survival in mice
• to study its effect on intracranial pressure (ICP) after subcutaneous administration in rats
• as a stimulant for renin release and subsequent increase in plasma angiotensin II (ANG II)

생화학적/생리학적 작용

"High ceiling" diuretic that strongly affects renal tubular action by increasing renal blood flow; antihypertensive.

Furosemide can block the Na⁺/K⁺/2Cl^- co-transporter in the ascending thick loop of Henle. It can enhance the synthesis of intrarenal prostaglandin. It enhances its ototoxicity in animals when used along with kanamycin. Furosemide is linked with thiamine insufficiency in individuals with heart failure.

Inhibits ion co-transport in the kidney.

특징 및 장점

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• 픽토그램: GHS08,GHS07
• 신호어: Danger
• 유해 및 위험 성명서: H302,H360FD
• 예방조치 성명서: P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405
• Hazard Classifications: Acute Tox. 4 Oral - Repr. 1B
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges