추천 제품
Quality Level
분석
≥98% (HPLC)
양식
solid
solubility
DMSO: soluble 18 mg/mL
H2O: insoluble
주관자
Roche
SMILES string
CC(C)NC(=O)NS(=O)(=O)c1cnccc1Nc2cccc(C)c2
InChI
1S/C16H20N4O3S/c1-11(2)18-16(21)20-24(22,23)15-10-17-8-7-14(15)19-13-6-4-5-12(3)9-13/h4-11H,1-3H3,(H,17,19)(H2,18,20,21)
InChI key
NGBFQHCMQULJNZ-UHFFFAOYSA-N
유전자 정보
human ... SLC12A1(6557)
유사한 제품을 찾으십니까? 방문 제품 비교 안내
애플리케이션
Torsemide has been used as an inhibitor of Na+ Cl- co-transporter in transgenic Arabidopsis thaliana plants1.
생화학적/생리학적 작용
Torsemide functions in the thick ascending limb of the loop of Henle and enhances the excretion of sodium, chloride and water from the luminal side of the cells. Furthermore, torsemide can treat oedematous conditions that are associated with diseases such as liver cirrhosis, kidney disorders and chronic congestive heart failure2.
Torsemide is a loop diuretic and inhibitor of the Na+/K+/2Cl- carrier system.
Torsemide is a loop diuretic of the pyridine-sulfonylurea class with antialdosteronergic properties and inhibitor of the Na+/K+/2Cl- carrier system.
특징 및 장점
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
제조 메모
Torsemide is soluble in DMSO at 18 mg/ml and is insoluble in water.
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Eye Irrit. 2 - Repr. 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
dust mask type N95 (US), Eyeshields, Gloves
Livia Saleh et al.
Plant signaling & behavior, 8(6), e24259-e24259 (2013-04-23)
The involvement of chloride in salt stress symptoms and salt tolerance mechanisms in plants has been less investigated in the past. Therefore, we studied the salt-induced chloride influx in Arabidopsis expressing the GFP-based anion indicator Clomeleon. High salt concentrations induce
H A Friedel et al.
Drugs, 41(1), 81-103 (1991-01-01)
Torasemide (torsemide) is a high-ceiling loop diuretic which acts on the thick ascending limb of the loop of Henle to promote rapid and marked excretion of water, sodium and chloride. Like furosemide (frusemide), its major site of action is from
D V Preobrazhenskiĭ et al.
Kardiologiia, 51(4), 67-73 (2011-06-01)
Torasemide is a loop diuretic and has been used for the treatment of both acute and chronic congestive heart failure (CHF) and arterial hypertension (AH). Torasemide is similar to other loop diuretics in terms of its mechanism of diuretic action.
Loop diuretic therapy in left ventricular systolic dysfunction: has familiarity bred contempt for a critical but potentially nephrotoxic cardio renal therapy?
Robert J MacFadyen et al.
European journal of heart failure, 12(7), 649-652 (2010-06-26)
M J Barbanoj et al.
Clinical and experimental pharmacology & physiology, 36(5-6), 469-477 (2009-08-14)
1. The main objective of the present study was to compare the bioavailability/bioequivalence of a new prolonged-release (PR) formulation of torasemide with an immediate-release (IR) formulation. In addition, we assessed the pharmacokinetics of both formulations, as well as the urine
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