SML0420

TAPI-2 acetate salt

≥98% (HPLC)

• 동의어(들): N-(R)-(2-(Hydroxyaminocarbonyl)methyl)-4-methylpentanoyl-L-t-butyl-glycine-L-alanine 2-aminoethyl amide, Tumor necrosis factor-α protease inhibitor-2, TNF-α protease inhibitor-2
• 실험식(Hill 표기법): C₁₉H₃₇N₅O₅ · xC₂H₄O₂
• CAS Number: 689284-12-6
• Molecular Weight: 415.53 (free base basis)
• MDL number: MFCD22666396
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329825415
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• 양식: lyophilized powder
• 색상: white to off-white
• 배송 상태: wet ice
• 저장 온도: −20°C
• SMILES string: CC(O)=O.CC(C)C[C@H](CC(=O)NO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)NCCN)C(C)(C)C
• InChI: 1S/C19H37N5O5.C2H4O2/c1-11(2)9-13(10-14(25)24-29)17(27)23-15(19(4,5)6)18(28)22-12(3)16(26)21-8-7-20;1-2(3)4/h11-13,15,29H,7-10,20H2,1-6H3,(H,21,26)(H,22,28)(H,23,27)(H,24,25);1H3,(H,3,4)/t12-,13+,15+;/m0./s1
• InChI key: LMUSZKBIFGOFBD-RAFLFFCLSA-N

설명

애플리케이션

TAPI-2 acetate salt has been used to inhibit protease activity in HepG2 cells.

생화학적/생리학적 작용

TAPI-2 is a potent inhibitor matrix metalloproteinases and TACE (TNF-α convertase/ADAM17/α-secretase).

TAPI-2 is a potent inhibitor matrix metalloproteinases and TACE (TNF-α convertase/ADAM17/α-secretase). It blocks the shedding of several cell surface proteins such as β-amyloid precursor protein, inhibits TNF-α release as well as a diverse variety of membrane-anchored cytokines, cell adhesion molecules, receptors, ligands. TAPI-2 is considered a fairly broad metalloproteinase inhibitor, but it much more selective for TACE than GM6001.

특징 및 장점

This compound is featured on the Cytokine Receptors (Tumor Necrosis Receptor Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable