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Merck
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Key Documents

579050

Sigma-Aldrich

TAPI-0

≥96% (HPLC), solid, collagenase, gelatinase, and TACE inhibitor, Calbiochem®

동의어(들):

TAPI-0, N-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-naphthylalanyl-L-alanine Amide, TNF-α Protease Inhibitor-0

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About This Item

실험식(Hill 표기법):
C24H32N4O5
CAS Number:
143457-40-3
Molecular Weight:
456.53
UNSPSC 코드:
12352200
NACRES:
NA.77

product name

TAPI-0, TAPI-0, CAS 143457-40-3, is a hydroxamate-based inhibitor of collagenase, gelatinase, and TACE (TNF-α converting enzyme/ADAM17; IC₅₀ = 100 nM).

Quality Level

100

분석

≥96% (HPLC)

형태

solid

제조업체/상표

Calbiochem®

저장 조건

OK to freeze
desiccated (hygroscopic)
protect from light

색상

white

solubility

50% acetic acid: 1 mg/mL
DMSO: 5 mg/mL

배송 상태

ambient

저장 온도

−20°C

InChI

1S/C24H32N4O5/c1-14(2)10-19(13-21(29)28-33)23(31)27-20(24(32)26-15(3)22(25)30)12-16-8-9-17-6-4-5-7-18(17)11-16/h4-9,11,14-15,19-20,33H,10,12-13H2,1-3H3,(H2,25,30)(H,26,32)(H,27,31)(H,28,29)/t15-,19?,20-/m0/s1

InChI key

CRCPLBFLOSEABN-VBSNWNEZSA-N

일반 설명

A hydroxamate-based inhibitor of collagenase, gelatinase, and TACE (TNF-α converting enzyme/ADAM17; IC50 = 100 nM). Blocks spontaneous and PMA-induced release of TNF-α in transfected COS 7 cells.
A hydroxymate-based inhibitor of collagenase, gelatinase, and TACE [(TNF-α convertase; ADAM17 (IC50 = 100 nM)]. Blocks spontaneous and PMA-induced release of TNF-α from transfected COS-7 cells.

생화학적/생리학적 작용

Cell permeable: no
Primary Target
TNF-α converting enzyme/ADAM17
Product does not compete with ATP.
Reversible: no
Target IC50: 100 nM against TACE (TNF-α converting enzyme/ADAM17)

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

기타 정보

Hooper, N.M., et al. 1997. Biochem. J.321, 265.
Mullberg, J., et al. 1995. J. Immunol.155, 5198.
Mohler, K.M., et al. 1994. Nature370, 218.

법적 정보

Manufactured exclusively by Peptides International, Louisville, Kentucky, USA.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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