A6011

Acetazolamide

≥99%, powder

• 동의어(들): 5-Acetamido-1,3,4-thiadiazole-2-sulfonamide, N-(5-Sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide, N-(5-[Aminosulfonyl]-1,3,4-thiadiazol-2-yl)acetamide
• 실험식(Hill 표기법): C₄H₆N₄O₃S₂
• CAS Number: 59-66-5
• Molecular Weight: 222.25
• EC Number: 200-440-5
• MDL number: MFCD00003105
• UNSPSC 코드: 12352202
• PubChem Substance ID: 57653866
• NACRES: NA.77

속성

• 생물학적 소스: synthetic
• 분석: ≥99%
• 양식: powder
• pKa: 7.2
• mp: 258-259 °C
• solubility: 1 M NH4OH: 50 mg/mL; DMSO: soluble; methanol and ethanol: slightly soluble
• SMILES string: CC(=O)Nc1nnc(s1)S(N)(=O)=O
• InChI: 1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)
• InChI key: BZKPWHYZMXOIDC-UHFFFAOYSA-N
• 유전자 정보: human ... CA1(759) , CA12(771) , CA14(23632) , CA2(760) , CA3(761) , CA4(762) , CA5A(763) , CA5B(11238) , CA9(768) ; mouse ... Car13(71934) , Car5a(12352) ; rat ... Car2(54231) , Car4(29242)

설명

애플리케이션

Acetazolamide has been used:

• to study its protective effect on steatotic liver grafts against cold ischemia reperfusion injury{49)
• to determine its ability to bind isolated porcine retinal pigment epithelium (RPE) melanin by cassette dosing and rapid equilibrium dialysis inserts
• to validate the in vitro gastrulation model of P19C5 stem cells for developmental toxicity screening assays
• to study its inhibitory effect on melanogenesis through enzyme kinetic, in vitro, in vivo and in silico analyses in zebrafish and in A375 human melanoma cells

Carbonic anhydrase inhibitor; increases cerebral blood flow.

생화학적/생리학적 작용

Acetazolamide is a member of sulfonamide drug family. It as an ability to inhibit the activity of carbonic anhydrase. It rapidly increases cerebral blood flow (CBF) and is used as an investigative tool in CBF studies. Acetazolamide acts as a therapeutic agent for epilepsy, glaucoma and pseudotumor cerebri.

Inhibits water permeability of membranes by interacting with aquaporins

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H315,H319
• 예방조치 성명서: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves