S0266

Spermidine

BioReagent, for molecular biology, suitable for cell culture, ≥98%

• 동의어(들): 1,8-Diamino-4-azaoctane, N-(3-Aminopropyl)-1,4-diaminobutane
• Linear Formula: NH₂(CH₂)₃NH(CH₂)₄NH₂
• CAS Number: 124-20-9
• Molecular Weight: 145.25
• Beilstein: 1698591
• EC Number: 204-689-0
• MDL number: MFCD00008229
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24899434
• NACRES: NA.52

속성

• Grade: for molecular biology
• Quality Level: 200
• 제품 라인: BioReagent
• 분석: ≥98%
• 양식: solid or liquid
• 분자량: 145.25 (AMU)
• 기술: cell culture | mammalian: suitable
• refractive index: n20/D 1.479 (lit.)
• density: 0.925 g/mL at 25 °C (lit.)
• 외래 활성: DNase, RNase, and protease, none detected
• 저장 온도: room temp
• SMILES string: NCCCCNCCCN
• InChI: 1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2
• InChI key: ATHGHQPFGPMSJY-UHFFFAOYSA-N
• 유전자 정보: rat ... Ppm1a(24666)

설명

일반 설명

Spermidine belongs to the natural polyamines, that are found in chloroplasts and in bacterial or eukaryotic cells.

애플리케이션

Spermidine has been used in the preparation of gold beads and as a component in nuclei isolation buffer (NIB).

Spermidine is suitable for use in molecular biology buffers and for precipitation of DNA >100 bp in length. It was used to deliver DNA in plants and mammalian cells by particle bombardment technique.

생화학적/생리학적 작용

Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; Stimulates T₄ polynucleotide kinase activity.

Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; may be used for purification of DNA binding proteins. Stimulates T₄ polynucleotide kinase activity.

Spermidine helps to maintain the proper activity of gene expression. This polyamine plays a key role in intermediate metabolism. It also serves as an inhibitor of the acetyl transferase activity of E1A-associated protein p300 (EP300). Spermidine participates in cell growth.

주의사항

Solutions should be sterile-filtered, not autoclaved, if sterile solution is necessary. Spermidine deaminates with time; solutions should be stored frozen. Prepare new solutions frequently.

안전성 정보

• 픽토그램: GHS05
• 신호어: Danger
• 유해 및 위험 성명서: H314
• 예방조치 성명서: P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363 - P405
• Hazard Classifications: Eye Dam. 1 - Skin Corr. 1B
• Storage Class Code: 8A - Combustible corrosive hazardous materials
• WGK: WGK 3
• Flash Point (°F): 233.6 °F - closed cup
• Flash Point (°C): 112 °C - closed cup
• 개인 보호 장비: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter