D8375

2-Deoxy-D-glucose

≥98% (GC), crystalline

• 동의어(들): 2-Deoxyglucose, 2-Deoxy-D-arabinohexose
• 실험식(Hill 표기법): C₆H₁₂O₅
• CAS Number: 154-17-6
• Molecular Weight: 164.16
• Beilstein: 1723331
• EC Number: 205-823-0
• MDL number: MFCD00151328
• UNSPSC 코드: 12352201
• PubChem Substance ID: 24894205
• NACRES: NA.25

속성

• 생물학적 소스: synthetic
• 분석: ≥98% (GC)
• 양식: crystalline
• 기술: gas chromatography (GC): suitable; inhibition assay: suitable
• 색상: white to off-white
• mp: 146-147 °C (lit.)
• solubility: H₂O: 0.250 g/5mL
• 응용 분야: clinical research; life science and biopharma; metabolomics
• 저장 온도: 2-8°C
• SMILES string: OC[C@@H](O)[C@@H](O)[C@H](O)CC=O
• InChI: 1S/C6H12O5/c7-2-1-4(9)6(11)5(10)3-8/h2,4-6,8-11H,1,3H2/t4-,5-,6+/m1/s1
• InChI key: VRYALKFFQXWPIH-PBXRRBTRSA-N

설명

일반 설명

2-Deoxy-D-glucose, a non-metabolizable glucose analogue, disrupts glycolysis by targeting hexokinase, the rate-limiting step in glycolysis. Phosphorylated to 2-DG-P by hexokinase, it accumulates in the cell, depleting cellular ATP. This approach, effective in starving and killing cancer cells, may also inhibit virus cells reliant on glycolysis for replication. This versatile molecule finds application in cancer, virology, metabolomics and biochemical research.

애플리케이션

2-Deoxy-D-glucose (2-DG) is used in glucoprivic feeding research to invoke and study the processes of counter-regulatory response (CRR). 2-Deoxy-D-glucose is used in the development of anti-cancer strategies that involve radio- and chemosensitization and oxidative stress.

생화학적/생리학적 작용

2-Deoxy-D-Glucose (2-Deoxyglucose) is a glucose analog that inhibits glycolysis via its actions on hexokinase, the rate limiting step of glycolysis. It is phosphorylated by hexokinase to 2-DG-P which can not be further metabolized by phosphoglucose isomerase. This leads to the accumulation of 2-DG-P in the cell and the depletion in cellular ATP. In vitro, 2-Deoxyglucose has been shown to induce autophagy, increase ROS production, and activate AMPK.

특징 및 장점

• High-purity compound suitable for a wide variety of research applications

포장

Bottomless glass bottle. Contents are inside inserted fused cone.

기타 정보

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

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안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)