P5248

Etidronate disodium hydrate

≥97% (NMR), solid

• 동의어(들): Dihydrogen (1-hydroxyethylidene)bisphosphonate disodium hydrate
• 실험식(Hill 표기법): C₂H₆Na₂O₇P₂ · xH₂O
• CAS Number: 7414-83-7
• Molecular Weight: 249.99 (anhydrous basis)
• EC Number: 231-025-7
• MDL number: MFCD00152567
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329820220
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥97% (NMR)
• 양식: solid
• 색상: white
• mp: >300 °C
• solubility: H₂O: ≥10 mg/mL
• 저장 온도: 2-8°C
• SMILES string: [Na+].[Na+].CC(O)(P(O)([O-])=O)P(O)([O-])=O
• InChI: 1S/C2H8O7P2.2Na/c1-2(3,10(4,5)6)11(7,8)9;;/h3H,1H3,(H2,4,5,6)(H2,7,8,9);;/q;2*+1/p-2
• InChI key: GWBBVOVXJZATQQ-UHFFFAOYSA-L

설명

애플리케이션

Etidronate disodium hydrate has been used in the synthesis of bisphosphonate derivatives of adenosine triphosphate (ATP)by T4 RNA ligase. It has also been sued to inhibit human farnesyl diphosphate synthase (FDPS).

생화학적/생리학적 작용

Etidronate helps to guard chronic ocular hypertension prompted retinal oxidative stress. It stimulates the development of retinal ganglion cells through insulin-like growth factor 1 (IGF-1) signaling pathway. It may possess neuroprotective effects in in vivo and in vitro rat model of glaucoma. Etidronate belongs to bisphosphonates.

Bisphosphonate antiresorptive agent. Less potent inhibitor of farnesyl diphosphate synthase (IC₅₀ = 80 μM) as compared to the nitrogen containing bisphosphonates

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves