A4978

Alendronate sodium trihydrate

≥97% (NMR), powder

• 동의어(들): 4-amino-1-hydroxy-1-phosphonobutyl phosphonic acid, monosodium, MK-217
• 실험식(Hill 표기법): C₄H₁₂NaNO₇P₂ · 3 H₂O
• CAS Number: 121268-17-5
• Molecular Weight: 325.12
• MDL number: MFCD01748233
• UNSPSC 코드: 41106300
• PubChem Substance ID: 24724391
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥97% (NMR)
• 양식: powder
• 색상: white
• solubility: water, double-distilled: 10 mg/mL
• 저장 온도: −20°C
• SMILES string: [Na+].[H]O[H].[H]O[H].[H]O[H].NCCCC(O)(P(O)(O)=O)P(O)([O-])=O
• InChI: 1S/C4H13NO7P2.Na.3H2O/c5-3-1-2-4(6,13(7,8)9)14(10,11)12;;;;/h6H,1-3,5H2,(H2,7,8,9)(H2,10,11,12);;3*1H2/q;+1;;;/p-1
• InChI key: DCSBSVSZJRSITC-UHFFFAOYSA-M
• 유전자 정보: human ... FDPS(2224)

설명

애플리케이션

Alendronate sodium trihydrate has been used:

• for calcium phosphate nanoparticles (nCaP)/ bisphosphonate (BP) coating on titanium implants and analyze its osteogenic capacity
• in osteogenic differentiation of human bone marrow stromal cells (hBMSCs) isolated from aged osteoporosis patients- and healthy-person
• to treat osteoblast progenitor cells and osteoblasts and study their effect on osteoblast behaviors using conventional assays and simple digital image analysis

생화학적/생리학적 작용

Alendronate is a nitrogen-containing bisphosphonate that is known to hinder the mevalonate pathway and limit osteoclastic function and activity. Alendronate sodium trihydrate is a bone resorption inhibitor, farnesyl diphosphate synthase inhibitor, and CD45 protein tyrosine phosphatase inhibitor.

Alendronate sodium trihydrate is a bone resorption inhibitor; farnesyl diphosphate synthase inhibitor (IC₅₀ = 460 nM); CD45 protein tyrosine phosphatase inhibitor.

저장 및 안정성

Following reconstitution, it is recommended to aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves