I5784

Ibandronate sodium salt

≥97% (NMR), solid

• 동의어(들): (1-Hydroxy-3-(methylpentylamino)propylidene)bisphosphonic acid sodium, Bondronat
• 실험식(Hill 표기법): C₉H₂₂NNaO₇P₂
• CAS Number: 138844-81-2
• Molecular Weight: 341.21
• MDL number: MFCD07197214
• UNSPSC 코드: 41106300
• PubChem Substance ID: 329815388
• NACRES: NA.77

속성

• 분석: ≥97% (NMR)
• 형태: solid
• 저장 조건: protect from light
• 색상: white
• solubility: H₂O: >10 mg/mL
• 주관자: Roche
• 저장 온도: 2-8°C
• SMILES string: [Na+].CCCCCN(C)CCC(O)(P(O)(O)=O)P(O)([O-])=O
• InChI: 1S/C9H23NO7P2.Na/c1-3-4-5-7-10(2)8-6-9(11,18(12,13)14)19(15,16)17;/h11H,3-8H2,1-2H3,(H2,12,13,14)(H2,15,16,17);/q;+1/p-1
• InChI key: LXLBEOAZMZAZND-UHFFFAOYSA-M
• 유전자 정보: human ... FDPS(2224)

설명

애플리케이션

Ibandronate sodium salt has been used to study its effect on the proliferation and ultrastructure of Leishmania and Giardia by the generation of concentration curves. It has also been used to elucidate the route by which nitrogen-containing bisphosphonates (N-BPs) enter the cytosol and inhibit their molecular target.

생화학적/생리학적 작용

Ibandronate is a nitrogen-containing bisphosphonate (N-BP). It potentially inhibits mevalonate pathway in osteoclasts. Thus, ibandronate is effectively used to treat osteoporosis and other bone-related diseases.

Ibandronate sodium inhibits farnesyl diphosphate synthase (IC₅₀ = 20 nM). Ibandronate sodium is also a bone resorption inhibitor. It has been investigated for in vitro anti-tumor effects, such as apoptosis induction, inhibitor of cell growth, inhibition of invasive behavior, and inhibition of angiogenesis and for its in vivo role in various cancers including breast and prostate cancers.

특징 및 장점

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable