추천 제품
생물학적 소스
rabbit
Quality Level
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
양식
lyophilized powder
종 반응성
human, mouse, rat
기술
immunohistochemistry: suitable using mouse brain sections
western blot: 1:200 using rat brain membranes or human platelets
UniProt 수납 번호
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... P2RY12(64805)
mouse ... P2ry12(70839)
rat ... P2ry12(64803)
일반 설명
Purinergic receptor or platelet adenosine 5′-diphosphate (ADP) receptor P2Y12 is a G-protein-coupled receptor. The gene encoding it is localized on human chromosome 3q25.1.
면역원
peptide corresponding to amino acid residues 125-142 of human P2Y12. This epitope is highly homologous in rat and mouse (16/18 residues identical).
애플리케이션
Anti-Purinergic Receptor P2Y12 antibody produced in rabbit has been used in Western blotting.
생화학적/생리학적 작용
Purinergic receptor or platelet adenosine 5′-diphosphate (ADP) receptor P2Y12 has a role in platelet aggregation induced by ADP. Dysfunctional mutations in the protein have been linked with bleeding disorders. Studies have indicated that mice deficient in the P2Y12 receptor show decreased tumor metastasis.
물리적 형태
Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Thomas H Smith et al.
The Journal of biological chemistry, 292(33), 13867-13878 (2017-06-28)
Vascular inflammation and thrombosis require the concerted actions of several different agonists, many of which act on G protein-coupled receptors (GPCRs). GPCR dimerization is a well-established phenomenon that can alter protomer function. In platelets and other cell types, protease-activated receptor-4
Leukotriene E4 induces MUC5AC release from human airway epithelial NCI-H292 cells
Hideaki Shirasaki
Allergology International (2014)
Aspirin and P2Y12 inhibition attenuate platelet-induced ovarian cancer cell invasion
Niamh M
BMC Cancer (2015)
Expression and Localization of Purinergic P2Y12 Receptor in Human Nasal Mucosa
Hideaki Shirasaki
Allergology International (2013)
Supplementary Table 1. Sample demographics for participants included in genome-wide association analyses
Hypertension (2016)
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