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Merck
모든 사진(2)

Key Documents

P8232

Sigma-Aldrich

Anti-P2X7 Purinergic Receptor antibody produced in rabbit

affinity isolated antibody, lyophilized powder

동의어(들):

Anti-P2X₇ Antibody, P2X₇ Receptor Detection, Rabbit Anti-P2X₇

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About This Item

MDL number:
UNSPSC 코드:
12352203
NACRES:
NA.41

생물학적 소스

rabbit

Quality Level

결합

unconjugated

항체 형태

affinity isolated antibody

항체 생산 유형

primary antibodies

클론

polyclonal

형태

lyophilized powder

종 반응성

human, mouse, rat

기술

immunohistochemistry: suitable
western blot: 1:200-1:1,000

UniProt 수납 번호

배송 상태

dry ice

저장 온도

−20°C

타겟 번역 후 변형

unmodified

유전자 정보

human ... P2RX7(5027)
mouse ... P2rx7(18439)
rat ... P2rx7(29665)

일반 설명

Purinergic receptor P2X7 is an ATP-gated cation channel. It is expressed in retinal pigmented epithelium and neural retina. The gene encoding this protein is localized on human chromosome 12.

면역원

Peptide (C)KIRKEFPKTQGQYSGFKYPY, corresponding to amino acid residues 576-595 of rat P2X7 Receptor (Accession Q64663). Intracellular, C-terminus.

애플리케이션

Anti-P2X7 Purinergic Receptor antibody produced in rabbit has been used in
  • immunoprecipitation
  • immunofluorescence and confocal microscopy
  • western blotting

생화학적/생리학적 작용

Purinergic receptor P2X7 has a role in immunological processes. It has a role during oxidative stress under pathological conditions. The channel is permeable to Na+, Ca2+ and K+. Prolonged activation of the channel under some pathological conditions leads to the passage of large molecules and ultimately cell death. P2X7 may be involved in the release of interleukin-1β (IL-1β) and indirectly initiate an inflammatory cascade.

물리적 형태

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide.

저장 및 안정성

Prior to reconstitution, store at –20°C. After reconstitution, the stock antibody solution may be stored at 2–8°C for up to two weeks. For extended storage, freeze at -20°C, or below, in working aliquots. Repeated freezing and thawing is not recommended. Storage in "frost-free" freezers is not recommended. Centrifuge all antibody preparations before use (10,000 x g 5 min). Working dilution samples should be discarded if not used within 12 hours.

기타 정보

In order to obtain the best results using various techniques and preparations, we recommend determining the optimal working dilutions by titration.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

13 - Non Combustible Solids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Lack of the P2X7 receptor protects against AMD-like defects and microparticle accumulation in a chronic oxidative stress-induced mouse model of AMD.
Carver KA
Biochemical and Biophysical Research Communications, 482(1), 81-86 (2017)
The P2X7 receptor directly interacts with the NLRP3 inflammasome scaffold protein
Alessia Franceschini
Faseb Journal (2015)
Roshni Thakkar et al.
Oxidative medicine and cellular longevity, 2016, 8309031-8309031 (2016-11-16)
17β-Estradiol (E2) is a well-known neuroprotective factor in the brain. Recently, our lab demonstrated that the neuroprotective and cognitive effects of E2 require mediation by the estrogen receptor (ER) coregulator protein and proline-, glutamic acid-, and leucine-rich protein 1 (PELP1).
Autophagy and ATP-induced anti-apoptosis in antigen presenting cells (APC) follows the cytokine storm in patients after major trauma
E. Marion Schneider
Journal of Cell Communication and Signaling, 5, 145-156 (2011)
Qing-Bing Zha et al.
Frontiers in immunology, 7, 597-597 (2016-12-27)
Adenosine triphosphate (ATP) is released by bacteria and host cells during bacterial infection as well as sterile tissue injury, acting as an inducer of inflammasome activation. Previous studies have shown that ATP treatment leads to AMP-activated protein kinase (AMPK) activation.

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