추천 제품
생물학적 소스
rabbit
Quality Level
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
형태
lyophilized powder
종 반응성
human, rat, mouse
기술
western blot: 1:200 using rat brain lysate and human cell lines
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... P2RX7(5027)
mouse ... P2rx7(18439)
rat ... P2rx7(29665)
일반 설명
P2X receptors are membrane-bound ion channels that are activated by extracellular ATP. These receptors consist of seven known isoforms ranging from P2X1 to P2X7 . P2X7 modulates several cellular functions such as cell death, cytokine release and mRNA synthesis . Anti-Purinergic Receptor P2(X7) (extracellular) antibody is specific for P2X7 in rats and mice. The antibody also reacts with human K562 (Chronic myelogeneous leukemia); WEHI-231 (Lymphoma, B lymphocyte) and HL-60 (promyelocytic leukemia) cell lines.
면역원
Synthetic peptide corresponding to residues 136-152 of mouse P2X7 receptor. This antigenic epitope is identical in humans and rats; whereas in bovines, only 14/17 residues are identical.
애플리케이션
Anti-Purinergic Receptor P2(X7) (extracellular) antibody is suitable for use in immunoblot and western blot (1:200, using rat brain lysate and human cell lines).
물리적 형태
Lyophilized from phosphate buffered saline, pH 7.4, 1% BSA, and 0.05% sodium azide.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Y Ding et al.
Journal of the autonomic nervous system, 81(1-3), 289-294 (2000-06-28)
A role for ATP in nociception and pain induction was proposed on the basis of human psychophysical experiments shortly after the formulation of the purinergic hypothesis. Following the pharmacological definition of distinct P2X and P2Y purinergic receptor subtypes by Burnstock
Molecular Physiology of P2X Receptors.
North, R., A.
Physical Review, 82(4), 1013-1067 (2002)
A Faroni et al.
Journal of neuroscience research, 92(10), 1259-1269 (2014-06-07)
Adenosine-5'-triphosphate, the physiological ligand of P2X receptors, is an important factor in peripheral nerve development. P2X7 receptor is expressed in Schwann cells (SCs), but the specific effects of P2X7 purinergic signaling on peripheral nerve development, myelination, and function are largely
Georg Ebeling et al.
PloS one, 9(6), e100282-e100282 (2014-06-19)
P2X7 receptors, ATP-gated cation channels, are specifically expressed in alveolar epithelial cells. The pathophysiological function of this lung cell type, except a recently reported putative involvement in surfactant secretion, is unknown. In addition, P2X7 receptor-deficient mice show reduced inflammation and
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