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Merck
모든 사진(2)

Key Documents

N3136

Sigma-Aldrich

Naltrexone hydrochloride

≥99% (HPLC), powder, opioid receptor antagonist

동의어(들):

Naltrexone HCl

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About This Item

실험식(Hill 표기법):
C20H23NO4 · HCl
CAS Number:
Molecular Weight:
377.86
Beilstein:
3580333
EC Number:
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77

product name

Naltrexone hydrochloride,

형태

powder

Quality Level

주관자

Novartis

저장 온도

2-8°C

SMILES string

Cl.Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O)CC6CC6

InChI

1S/C20H23NO4.ClH/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11;/h3-4,11,15,18,22,24H,1-2,5-10H2;1H/t15-,18+,19+,20-;/m1./s1

InChI key

RHBRMCOKKKZVRY-ITLPAZOVSA-N

유사한 제품을 찾으십니까? 방문 제품 비교 안내

애플리케이션

Naltrexone hydrochloride has been used:
  • as an opioid antagonist, to analyse its effect on ethanol preference using Caenorhabditis elegans as a model
  • to determine its effectiveness in reducing the preference for substance of abuse (SOA) like nicotine and cocaine using Caenorhabditis elegans as a model
  • in the preparation of combinatorial drug, PXT3003 for treating Charcot-Marie-Tooth disease 1A (CMT1A) transgenic rat model Pmp22

생화학적/생리학적 작용

Competitive antagonist for μ, κ, δ, and σ-opioid receptors; has greater oral efficacy and longer duration of action than naloxone.

특징 및 장점

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

픽토그램

Exclamation mark

신호어

Warning

유해 및 위험 성명서

예방조치 성명서

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

dust mask type N95 (US), Eyeshields, Gloves


시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Caenorhabditis elegans show preference for stimulants and potential as a model organism for medications screening
Engleman EA, et al.
Frontiers in Physiology, 9, 7-16 (2018)
Caenorhabditis elegans as a model system to identify therapeutics for alcohol use disorders
Katner SN, et al.
Behavioural Brain Research, 365, 7-16 (2019)
P Bienkowski et al.
European journal of pharmacology, 374(3), 321-327 (1999-07-28)
It has been repeatedly reported that endogenous opioid pathways play an important role in ethanol drinking behaviour. In line with these findings, a non-selective opioid receptor antagonist, naltrexone, seems to reduce relapse rates in detoxified alcoholics. The aim of the
Raquel Moreno-Vicente et al.
Journal of pharmaceutical and biomedical analysis, 114, 105-112 (2015-06-04)
A bioanalytical method using high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed and validated for simultaneous quantification of heroin, its main metabolites and naloxone. In addition, naltrexone was detected qualitatively. This method was used to analyse human plasma samples from
Early short-term PXT3003 combinational therapy delays disease onset in a transgenic rat model of Charcot-Marie-Tooth disease 1A (CMT1A)
Prukop T, et al.
Testing, 14(1), e0209752-e0209752 (2019)

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