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Merck
모든 사진(4)

주요 문서

L2637

Sigma-Aldrich

Lipopolysaccharides from Escherichia coli O55:B5

purified by gel-filtration chromatography

동의어(들):

LPS

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About This Item

EC Number:
MDL number:
UNSPSC 코드:
12352201
NACRES:
NA.25

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생물학적 소스

Escherichia coli (O55:B5)

Quality Level

형태

lyophilized powder

정제법

gel-filtration chromatography

불순물

<3% Protein

색상

white to faint gray

solubility

water: soluble

배송 상태

ambient

저장 온도

2-8°C

유사한 제품을 찾으십니까? 방문 제품 비교 안내

유사한 품목 비교

전체 비교 보기

차이점 표시

1 of 4

이 품목
52599-U52607-U52601-U
pore size

70 Å pore size

pore size

70 Å pore size

pore size

70 Å pore size

pore size

70 Å pore size

separation technique

reversed phase

separation technique

reversed phase

separation technique

reversed phase

separation technique

reversed phase

extent of labeling

18% C loading

extent of labeling

18% C loading

extent of labeling

18% C loading

extent of labeling

18% C loading

matrix active group

C18 (octadecyl) bonding, polymerically bonded

matrix active group

C18 (octadecyl) bonding, polymerically bonded

matrix active group

C18 (octadecyl) bonding, polymerically bonded

matrix active group

C18 (octadecyl) bonding, polymerically bonded

matrix

silica gel (irregularly shaped, acid washed)

matrix

silica gel (irregularly shaped, acid washed)

matrix

silica gel (irregularly shaped, acid washed)

matrix

silica gel (irregularly shaped, acid washed)

일반 설명

This product is extracted from E. coli serotype O55:B5 and purified by gel filtration. The source strain is CDC 1644-70. The LPS O55:B5 has been used to stimulate human peritoneal macrophages at 1 ng/ml and to stimulate equine peritoneal macrophages at 1-100 ng/ml.

애플리케이션

Lipopolysaccharides (LPSs) are characteristic components of the cell wall of Gram-negative bacteria. LPS and its lipid A moiety stimulate cells of the innate immune system by the Toll-like receptor 4 (TLR4), a member of the Toll-like receptor protein family, which recognizes common pathogen-associated molecular-patterns (PAMPs).

생화학적/생리학적 작용

Lipopolysaccharides (LPS) are localized in the outer layer of the membrane and are, in noncapsulated strains, exposed on the cell surface. They contribute to the integrity of the outer membrane, and protect the cell against the action of bile salts and lipophilic antibiotics.

제조 메모

The product is soluble in water (5 mg/ml) or cell culture medium (1 mg/ml) yielding a hazy, faint yellow solution. A more concentrated, though still hazy, solution (20 mg/ml) has been achieved in aqueous saline after vortexing and warming to 70-80 oC. Lipopolysaccharides are molecules that form micelles in every solvent. Hazy solutions are observed in water and phosphate buffered saline. Organic solvents do not give clearer solutions. Methanol yields a turbid suspension with floaters, while water yields a homogeneously hazy solution.

기타 정보

To gain a comprehensive understanding of our extensive range of Lipopolysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

픽토그램

Skull and crossbones

신호어

Danger

유해 및 위험 성명서

Hazard Classifications

Acute Tox. 2 Oral

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)


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    Francisco J Quintana et al.
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    B-cells integrate antigen-specific signals transduced via the B-cell receptor (BCR) and antigen non-specific co-stimulatory signals provided by cytokines and CD40 ligation in order to produce IgG antibodies. Toll-like receptors (TLRs) also provide co-stimulation, but the requirement for TLRs to generate
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    Chronic neuroinflammation is thought to play an etiological role in Alzheimer's disease (AD), which is characterized pathologically by amyloid and tau formation, as well as neuritic dystrophy and synaptic degeneration. The causal relationship between these pathological events is a topic

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