F4767

Filipin III from Streptomyces filipinensis

≥85% (HPLC)

• 동의어(들): Filimarisin
• 실험식(Hill 표기법): C₃₅H₅₈O₁₁
• CAS Number: 480-49-9
• Molecular Weight: 654.83
• MDL number: MFCD00466923
• UNSPSC 코드: 12352202
• PubChem Substance ID: 24894871
• NACRES: NA.77

속성

• Quality Level: 300
• 분석: ≥85% (HPLC)
• 형태: powder
• mp: 163-180 °C
• solubility: methanol: 9.80-10.20 mg/mL, clear, colorless to yellow
• 항생제 활성 스펙트럼: fungi; yeast
• 동작 모드: cell membrane | interferes
• 저장 온도: −20°C
• SMILES string: CCCCCC(O)C1C(O)CC(O)CC(O)CC(O)CC(O)CC(O)CC(O)C(C)=C\C=C\C=C\C=C\C=C\C(O)C(C)OC1=O
• InChI: 1S/C35H58O11/c1-4-5-11-16-31(42)34-33(44)22-29(40)20-27(38)18-25(36)17-26(37)19-28(39)21-32(43)23(2)14-12-9-7-6-8-10-13-15-30(41)24(3)46-35(34)45/h6-10,12-15,24-34,36-44H,4-5,11,16-22H2,1-3H3/b7-6+,10-8+,12-9+,15-13+,23-14-
• InChI key: IMQSIXYSKPIGPD-BWJOQPJXSA-N

설명

애플리케이션

Filipin has been used in a double staining procedure as a probe for the detection of lipoproteins in polyacrylamide gel and immobilized on nitrocellulose membranes. It is also widely used to localize and quantitate unesterified cholesterol by virtue of a specific fluorescent complex.

생화학적/생리학적 작용

Filipin is a polyene macrolide antibiotic and antifungal. The antifungal mechanism of action may be due to altering membrane permeability and associated functions by binding to membrane sterols. Filipin inhibits prion protein (PrP) endocytosis and causes the release of PrP from the plasma membrane.

기타 정보

Filipin III is the major component of 8 isomeric components in filipin.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H315,H319,H335
• 예방조치 성명서: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves