A7410

Amiloride hydrochloride hydrate

≥98% (HPLC), powder, T-type calcium channel blocker

• 동의어(들): N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride hydrate
• 실험식(Hill 표기법): C₆H₈ClN₇O · HCl · xH₂O
• CAS Number: 2016-88-8
• Molecular Weight: 266.09 (anhydrous basis)
• MDL number: MFCD03703482
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24277817
• NACRES: NA.77

속성

• product name: Amiloride hydrochloride hydrate, ≥98% (HPLC), powder
• Quality Level: 200
• 분석: ≥98% (HPLC)
• 형태: powder
• 색상: yellow
• mp: 285-288 °C (dec.)
• solubility: H₂O: 50 mg/mL, clear, yellow-green
• 주관자: Perrigo
• 저장 온도: room temp
• SMILES string: O.Cl.NC(=N)NC(=O)c1nc(Cl)c(N)nc1N
• InChI: 1S/C6H8ClN7O.ClH.H2O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;;/h(H4,8,9,13)(H4,10,11,14,15);1H;1H2
• InChI key: WDZJJRLYFQNCQL-UHFFFAOYSA-N
• 유전자 정보: human ... ABP1(26) , ACCN1(40) , ACCN2(41) , PLAU(5328) , SCNN1A(6337) , SCNN1B(6338) , SCNN1D(6339) , SCNN1G(6340) , SLC9A1(6548) , TNF(7124) ; mouse ... Abp1(76507) , Accn1(11418) , Accn2(11419) , Plau(18792) , Scnn1a(20276) , Scnn1b(20277) , Scnn1d(140501) , Scnn1g(20278) , Slc9a1(20544) ; rat ... Abp1(65029) , Accn1(25364) , Accn2(79123) , Plau(25619) , Scnn1a(25122) , Scnn1b(24767) , Scnn1g(24768) , Slc9a1(24782)

설명

애플리케이션

Amiloride is a selective T-type calcium channel blocker, an epithelial sodium channel blocker and a selective inhibitor of urokinase plasminogen activator (uPA). Amiloride has been used in a study to develop an alternative treatment for constipation.

생화학적/생리학적 작용

Selective T-type calcium channel blocker and blocker of epithelial sodium channel. Selective inhibitor of urokinase plasminogen activator (uPA).

특징 및 장점

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Acid-Sensing (Proton-gated) Ion Channels (ASICs) and Imidazoline Binding Sites pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Perrigo. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

주의사항

Protect from light.

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H301
• 예방조치 성명서: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges