추천 제품
분석
≥99%
solubility
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble 1.2 mg/mL
DMSO: soluble 5.4 mg/mL
H2O: insoluble
주관자
Wellspring
SMILES string
Nc1nc(N)c2nc(-c3ccccc3)c(N)nc2n1
InChI
1S/C12H11N7/c13-9-7(6-4-2-1-3-5-6)16-8-10(14)18-12(15)19-11(8)17-9/h1-5H,(H6,13,14,15,17,18,19)
InChI key
FNYLWPVRPXGIIP-UHFFFAOYSA-N
유전자 정보
human ... SCNN1A(6337) , SCNN1B(6338) , SCNN1G(6340)
유사한 제품을 찾으십니까? 방문 제품 비교 안내
애플리케이션
Triamterene has been used to study its effects on urokinase receptor (uPAR) induction in podocytes under in vitro conditions2. Triamterene has also been identified as an activator compound from a LOPAC library screen using a fluorogenic α-glucosidase assay3.
생화학적/생리학적 작용
Weak diuretic with potassium sparing properties; blocks Na+ reuptake in the kidneys.
특징 및 장점
This compound was developed by Wellspring. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
제조 메모
200 mg of triamterene is soluble in 4 ml of warm formic acid and yields a clear, yellow-green solution. Triamterene is also soluble in DMSO (5.4 mg/ml), and in 45% (w/v) aqueous 2-hydroxypropyl-β-cyclodextrin (1.2 mg/ml). However, it is insoluble in water.
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
표적 기관
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
이미 열람한 고객
Balraj S Heran et al.
The Cochrane database of systematic reviews, (1)(1), CD008167-CD008167 (2010-01-22)
Potassium-sparing diuretics, which block the epithelial sodium channel (ENaC), are widely prescribed for hypertension as a second-line drug in patients taking other diuretics (e.g. thiazide diuretics) and much less commonly prescribed as monotherapy. Therefore, it is essential to determine the
Junichi Enokizono et al.
Drug metabolism and disposition: the biological fate of chemicals, 36(6), 995-1002 (2008-03-07)
The role of breast cancer resistance protein (BCRP/ABCG2) in limiting the brain and testis penetration of xenobiotic compounds in the blood-brain and -testis barriers was investigated using Bcrp(-/-) mice. Tissue/plasma concentration ratios in the brain (K(p,brain)) and testis (K(p,testis)) obtained
Zhuomin Zhang et al.
The Analyst, 133(9), 1187-1194 (2008-08-19)
In competition sports, a diuretic is a substance widely prohibited by the World Anti-Doping Agency (WADA). In this paper, a sensitive, rapid and convenient analytical method for the determination of acidic [furosemide (FUROS) and bumetanide (BUMET)] and basic [triamterene (TRIAM)]
Yiqun Wu et al.
Clinical drug investigation, 31(11), 769-777 (2011-06-16)
A fixed-dose combination (FDC) of four compounds, hydrochlorothiazide 12.5 mg, triamterene 12.5 mg, dihydralazine 12.5 mg and reserpine 0.1 mg (HTDR), is widely used as an antihypertensive treatment in China. Although HTDR has been used in China for more than
Ali Asghar Ensafi et al.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 24(11), 1449-1454 (2008-11-11)
A square-wave voltammetric procedure for the electroanalytical determination of losartan and triamterene in Britton-Robinson buffer (pH 3.0, 0.1 mol L(-1)) as a supporting electrolyte containing 30 ng mL(-1) of copper ions was developed. Opposite to the case of triamterene, losartan
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