C8414

Clobazam

• 동의어(들): 7-Chloro-1-methyl-5-phenyl-1H-1,5-benzodiazepine-2,4-(3H,5H)-dione
• 실험식(Hill 표기법): C₁₆H₁₃ClN₂O₂
• CAS Number: 22316-47-8
• Molecular Weight: 300.74
• EC Number: 244-908-7
• MDL number: MFCD00079069
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24893060
• NACRES: NA.77

속성

• 양식: powder
• Quality Level: 200
• 약물 제어: USDEA Schedule IV; Home Office Schedule 4.1; psychotrope (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)
• SMILES string: CN1C(=O)CC(=O)N(c2ccccc2)c3cc(Cl)ccc13
• InChI: 1S/C16H13ClN2O2/c1-18-13-8-7-11(17)9-14(13)19(16(21)10-15(18)20)12-5-3-2-4-6-12/h2-9H,10H2,1H3
• InChI key: CXOXHMZGEKVPMT-UHFFFAOYSA-N
• 유전자 정보: human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , GABRD(2563) , GABRE(2564) , GABRG1(2565) , GABRG2(2566) , GABRG3(2567) , GABRP(2568) , GABRQ(55879)

설명

일반 설명

Clobazam is a benzodiazepine, comprising of B ring nitrogen placed in positions 1 and 5 contrary to 1,4-benzodiazepines. It is a ligand for γ-aminobutyric acid type A (GABAA) receptor and is metabolized by cytochrome P450 in the liver.

애플리케이션

Clobazam has been used as a benzodiazepine to test its effect on the activation of the human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR).

생화학적/생리학적 작용

Anxiolytic; ligand for the GABA_A receptor benzodiazepine modulatory site.

Clobazam interacts at α and γ2 subunits junction of the GABAA receptor. It is less sedative and elicits anxiolytic and anticonvulsant effects. Clobazam is more selective on the α2 subunit of the GABAA receptor than the α1 subunit. It is an antiseizure drug and is associated with antiepileptic activity. Clobazam is useful in treating chronic epileptic encephalopathy disorder, Lennox‐Gastaut syndrome. It is employed in epilepsy and seizure prevention adjunctive therapy.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302,H336,H412
• 예방조치 성명서: P261 - P264 - P270 - P271 - P273 - P301 + P312
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Chronic 3 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)