P4543

Valproic acid sodium salt

98%

• 동의어(들): 2-propylpentanoic acid sodium, Sodium 2-propylpentanoate, Sodium valproate
• 실험식(Hill 표기법): C₈H₁₅NaO₂
• CAS Number: 1069-66-5
• Molecular Weight: 166.19
• EC Number: 213-961-8
• MDL number: MFCD00078604
• UNSPSC 코드: 12352106
• eCl@ss: 42020819
• PubChem Substance ID: 24277744
• NACRES: NA.77

속성

• Quality Level: 200
• 분석: 98%
• 양식: powder
• solubility: H₂O: 50 mg/mL
• 주관자: Abbott
• SMILES string: [Na+].CCCC(CCC)C([O-])=O
• InChI: 1S/C8H16O2.Na/c1-3-5-7(6-4-2)8(9)10;/h7H,3-6H2,1-2H3,(H,9,10);/q;+1/p-1
• InChI key: AEQFSUDEHCCHBT-UHFFFAOYSA-M
• 유전자 정보: human ... ALDH5A1(7915)

설명

일반 설명

The antiepileptic effects of Valproic acid (VPA) are achieved by reducing high-frequency neuronal firing through the blockage of voltage-gated sodium, potassium, and calcium channels. This medication affects the biochemical occurrence of aura and impacts pain perception by modulating GABA or glutamate-mediated neurotransmission. Additionally, VPA influences signaling systems such as the Wnt/beta-catenin and ERK pathways, interfering with inositol and arachidonate metabolism. Furthermore, VPA is crucial in expressing multiple genes involved in cell survival, transcription regulation, ion homeostasis, signaltransduction, and cytoskeletal modifications. Both immediate biochemical effects and long-term genomic influences explain the underlying effect of VPA in treating various conditions.



Valproic acid is an anticonvulsant and mood-stabilizing drug. It is used to treat epilepsy and bipolar disorder. Valproic acid helps to repress the Warburg effect and the development of tumor in neuroblastoma.

애플리케이션

Valproic acid sodium salt has been used:

• in resazurin viability assay
• to systematically study its effects of clinical doses on brain volume and offspring behavior
• to study its effect on atherosclerotic lesion size
• in genetic expression studies in mice

생화학적/생리학적 작용

Anti-convulsant that also has efficacy as a mood stabilizer in bipolar disorder.

특징 및 장점

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• 픽토그램: GHS08,GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302,H361d
• 예방조치 성명서: P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405
• Hazard Classifications: Acute Tox. 4 Oral - Repr. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves