추천 제품
생물학적 소스
mouse
결합
unconjugated
항체 형태
ascites fluid
항체 생산 유형
primary antibodies
클론
6F9, monoclonal
분자량
antigen 94 kDa
포함
15 mM sodium azide
종 반응성
human, chicken, canine, bovine
기술
indirect immunofluorescence: 1:1,000 using cultured MDBK cells
microarray: suitable
western blot: 1:1,000 using cultured MDBK cells extract
동형
IgG1
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... CTNNB1(1499)
일반 설명
Monoclonal Anti- β -Catenin (mouse IgG1 isotype) is derived from the 6F9 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice. CTNNB1 (catenin β 1) gene is mapped to human chromosome 3p21. The protein encoded is also called as cadherin-associated protein.The encoded protein β-catenin is localized to the nucleus. Monoclonal antibody reacting specifically with β -catenin is an essential tool in defining the interactions and distributions of β -catenin and its relationships with other catenins and cadherins in various cells and tissues.
특이성
The antibody does not cross-react with plakoglobin (γ-catenin).
면역원
recombinant chicken β-catenin.
애플리케이션
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)
Immunofluorescence (1 paper)
Monoclonal Anti-β-Catenin antibody produced in mouse has been used in:
- immunohistochemistry
- immunofluorescence
- immunoblotting
생화학적/생리학적 작용
In Wnt/β-catenin signal pathway, β-Catenin participates as a signal transduction molecule. The pathway is associated with development, tissue homeostasis and oncogenic transcription. Upregulation of the gene is associated with glioma cell proliferation. The encoded protein has dual function that regulates the coordination of cell-cell adhesion by linking cytoskeleton and cellular junctions and gene transcription. Wnt/β-catenin signal pathway is known to induce progression of colon cancer progression. It is useful for differential diagnosis of Osteoblastoma (OB) and osteosarcoma (OS). β-catenin signaling pathway may contribute to cholangiocarcinoma (CCA) cell proliferation. Monoclonal antibody reacting specifically with β -catenin is an essential tool in defining the interactions and distributions of β -catenin and its relationships with other catenins and cadherins in various cells and tissues.
물리적 형태
Supplied as ascites fluid with 15 mM sodium azide as a preservative.
저장 및 안정성
For extended storage freeze in working aliquots. For continuous use, store at 2-8 °C. Repeated freezing and thawing, or storage in "frost-free" freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Jenny Schneider et al.
Development (Cambridge, England), 142(15), 2686-2695 (2015-06-28)
The nephron is the fundamental structural and functional unit of the kidney. Each mature nephron is patterned along a proximal-distal axis, with blood filtered at the proximal end and urine emerging from the distal end. In order to filter the
SOX7 Suppresses Wnt Signaling by Disrupting ?-Catenin/BCL9 Interaction.
Fan R, et al.
Dna and Cell Biology, 37(2), 126-132 (2018)
Suppression of canonical Wnt/?-catenin signaling by nuclear plakoglobin recapitulates phenotype of arrhythmogenic right ventricular cardiomyopathy
Gracia Gras E, et al.
The Journal of Clinical Investigation (2006)
Yang Wan et al.
Human pathology, 45(7), 1459-1465 (2014-04-22)
Osteoblastoma (OB) and osteosarcoma (OS) are 2 bone tumors that predominantly affect young adults. The clinical management of OS differs significantly from that of OB, and thus, accurate diagnosis of OB and OS is critical in determining appropriate treatment modality.
Damien P Hewitt et al.
Biology of reproduction, 75(1), 75-81 (2006-03-17)
Wnt genes regulate a diverse range of developmental processes, including placental formation. Activation of the WNT pathway results in translocation of beta-catenin (CTNNB1) into the nucleus and the subsequent activation of transcription factors that promote proliferation. The secreted frizzled related
문서
Cancer stem cell media, spheroid plates and cancer stem cell markers to culture and characterize CSC populations.
Cancer stem cell media, spheroid plates and cancer stem cell markers to culture and characterize CSC populations.
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