G7126

Glycine

≥99% (HPLC), suitable for western blotting, ReagentPlus^®

• 동의어(들): Aminoacetic acid, Aminoethanoic acid, Glycocoll
• Linear Formula: NH₂CH₂COOH
• CAS Number: 56-40-6
• Molecular Weight: 75.07
• Beilstein: 635782
• EC Number: 200-272-2
• MDL number: MFCD00008131
• UNSPSC 코드: 12352209
• eCl@ss: 32160406
• PubChem Substance ID: 24895290
• NACRES: NA.26

속성

• product name: Glycine, ReagentPlus^®, ≥99% (HPLC)
• Quality Level: 200
• 제품 라인: ReagentPlus^®
• 분석: ≥99% (HPLC)
• 형태: powder
• 기술: western blot: suitable
• 불순물: ≤0.01% Ammonia
• 손실: ≤0.2% loss on drying
• 색상: white to off-white
• pKa(25 °C): (1) 2.35, (2) 9.60; 2.35
• mp: 240 °C (dec.) (lit.)
• solubility: H₂O: 200 mg/mL, clear, colorless to faintly yellow
• 양이온 미량물: ≤0.01% (Ammonia (NH3))
• 작용기: amine; carboxylic acid
• 저장 온도: room temp
• SMILES string: NCC(O)=O
• InChI: 1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)
• InChI key: DHMQDGOQFOQNFH-UHFFFAOYSA-N
• 유전자 정보: rat ... Grin2a(24409)

설명

일반 설명

Glycine is a non-chiral amino acid. Glycine is a molecule with pI of 6.7, which is similar to the pH of stacking region in polyacrylamide gels. It has advantage of low mobility, hydrophobicity and it does not associate with proteins.

Glycine is a proteinogenic amino acid that plays a diverse array of roles in biochemistry and physiology. This non-essential, non-polar glucogenic amino acid acts as an inhibitory neurotransmitter in the central nervous system, but also works alongside glutamate as a co-agonist at NMDA receptors. As a precursor, glycine serves as a building block for various macromolecules, playing a crucial role in cellular processes.

Beyond its vital biological functions, glycine demonstrates remarkable versatility in various research applications. Its application as a biochemical reagent makes it invaluable in numerous assays and procedures. Its buffering capacity allows it to play a critical role in protein analysis techniques like SDS-PAGE and Western Blotting, chromatography, and cell culture. Glycine′s zwitterionic nature makes it an effective buffer across a range of pH values. In immunology research, it is widely used in the preparation of buffers for Western Blotting and other techniques. Additionally, its compatibility with various enzymes makes it useful in enzymatic assays like lactate determination. Furthermore, glycine contributes to the formulation of buffers for protein stabilization, pH control, and enzymatic reactions.

애플리케이션

• Glycine has been added in the transfer buffer during western blotting procedure.
• It has been used in the solution prepared for dissolving formazan crystals in the MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyltetrazolium bromide) cytotoxicity assay.
• It has been used for terminating the rat basophilic leukemia (RBL) assay.

생화학적/생리학적 작용

Glycine is an inhibitory neurotransmitter in the central nervous system and works as an allosteric regulator of NMDA (N-methyl-D-aspartate) receptors. It is involved in processing of motor and sensory data, thereby regulating movement, vision and audition.

Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

특징 및 장점

• Suitable for Cell Biology and Biochemical research
• High-quality compound suitable for multiple research applications

기타 정보

For additional information on our range of Biochemicals, please complete this form.

법적 정보

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)